1131832-45-5Relevant academic research and scientific papers
Diastereoselective synthesis of cyclic 1,3-aminoalcohols bearing CF3(CCl3)-groups
Shevchenko, Nikolay E.,R?schenthaler, Gerd-Volker,Mitiaev, Alexander S.,Lork, Enno,Nenajdenko, Valentine G.
experimental part, p. 637 - 644 (2009/04/03)
An aldol-type reaction of cyclic imines and cyclic lactims with carbonyl compounds activated by electron withdrawing trifluoromethyl or trichloromethyl groups proceeded without any catalyst under mild condition. β-Hydroxymethyl substituted cyclic imines or imidates are formed as a result of the reaction. The reduction of the prepared imines leads stereoselectively to the cyclic 1,3-aminoalcohols. Application of methyl trifluoropyruvate in this transformation opens an opportunity for the synthesis of γ-aminoacids derivatives which contain pyrrolidine moiety.
