Welcome to LookChem.com Sign In|Join Free

CAS

  • or

113204-35-6

Post Buying Request

113204-35-6 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

113204-35-6 Usage

General Description

Benzamide, 2,6-dichloro-N-4-pyridinyl- is a chemical compound that consists of a benzene ring with an amide group and two chlorine atoms, as well as a pyridine ring with a chlorine atom attached to the 2 and 6 positions. It is an organic compound that is generally used as a fungicide and agricultural pesticide due to its ability to control a wide range of plant pathogens, including fungi and bacteria. It works by inhibiting the growth and reproduction of these harmful organisms, thereby protecting crops and plants from disease. Additionally, it is also used as an intermediate in the synthesis of other chemical compounds. Safety precautions should be taken when handling this compound, as it may be harmful if swallowed, inhaled, or comes into contact with the skin.

Check Digit Verification of cas no

The CAS Registry Mumber 113204-35-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,3,2,0 and 4 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 113204-35:
(8*1)+(7*1)+(6*3)+(5*2)+(4*0)+(3*4)+(2*3)+(1*5)=66
66 % 10 = 6
So 113204-35-6 is a valid CAS Registry Number.

113204-35-6Relevant articles and documents

Lead identification of novel and selective TYK2 inhibitors

Liang, Jun,Tsui, Vickie,Van Abbema, Anne,Bao, Liang,Barrett, Kathy,Beresini, Maureen,Berezhkovskiy, Leo,Blair, Wade S.,Chang, Christine,Driscoll, James,Eigenbrot, Charles,Ghilardi, Nico,Gibbons, Paul,Halladay, Jason,Johnson, Adam,Bir Kohli, Pawan,Lai, Yingjie,Liimatta, Marya,Mantik, Priscilla,Menghrajani, Kapil,Murray, Jeremy,Sambrone, Amy,Xiao, Yisong,Shia, Steven,Shin, Young,Smith, Jan,Sohn, Sue,Stanley, Mark,Ultsch, Mark,Zhang, Birong,Wu, Lawren C.,Magnuson, Steven

, p. 175 - 187 (2013/10/01)

A therapeutic rationale is proposed for the treatment of inflammatory diseases, such as psoriasis and inflammatory bowel diseases (IBD), by selective targeting of TYK2. Hit triage, following a high-throughput screen for TYK2 inhibitors, revealed pyridine 1 as a promising starting point for lead identification. Initial expansion of 3 separate regions of the molecule led to eventual identification of cyclopropyl amide 46, a potent lead analog with good kinase selectivity, physicochemical properties, and pharmacokinetic profile. Analysis of the binding modes of the series in TYK2 and JAK2 crystal structures revealed key interactions leading to good TYK2 potency and design options for future optimization of selectivity.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 113204-35-6