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113220-25-0

(Z)-3-Cyclopentylamino-2-(2,3,4,5-tetrafluoro-benzoyl)-acrylic acid ethyl ester is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 113220-25-0 Structure

  • Basic information

    1. Product Name: (Z)-3-Cyclopentylamino-2-(2,3,4,5-tetrafluoro-benzoyl)-acrylic acid ethyl ester
    2. Synonyms:
    3. CAS NO:113220-25-0
    4. Molecular Formula:
    5. Molecular Weight: 359.32
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 113220-25-0.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: (Z)-3-Cyclopentylamino-2-(2,3,4,5-tetrafluoro-benzoyl)-acrylic acid ethyl ester(CAS DataBase Reference)
    10. NIST Chemistry Reference: (Z)-3-Cyclopentylamino-2-(2,3,4,5-tetrafluoro-benzoyl)-acrylic acid ethyl ester(113220-25-0)
    11. EPA Substance Registry System: (Z)-3-Cyclopentylamino-2-(2,3,4,5-tetrafluoro-benzoyl)-acrylic acid ethyl ester(113220-25-0)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 113220-25-0(Hazardous Substances Data)

113220-25-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 113220-25-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,3,2,2 and 0 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 113220-25:
(8*1)+(7*1)+(6*3)+(5*2)+(4*2)+(3*0)+(2*2)+(1*5)=60
60 % 10 = 0
So 113220-25-0 is a valid CAS Registry Number.

113220-25-0Downstream Products

113220-25-0Relevant articles and documents

1-Substituted 7--1-pyrrolidinyl>-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acids. New Quantitative Structure-Activity Relationships at N1 for the Quinolone Antibacterials

Domagala, John M.,Heifetz, Carl L.,Hutt, Marland P.,Mich, Thomas F.,Nichols, Jeffry B.,et al.

, p. 991 - 1001 (2007/10/02)

A series of 18 1-substituted 7--1-pyrrolidinyl>-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid (N1 analogues of CI-934) was synthesized and evaluated for antibacterial activity and DNA-gyrase inhibition.Correlations between the inhibition of DNA gyrase and antibacterial potency were established.A quantitative structure-activity relationship (QSAR) was derived by using the antibacterial potency of each of 11 strains of bacteria and the Gram-negative mean.The equations indicated that antibacterial potency was strongly dependent on STERIMOL length and width and the level of unsaturation of the N1 substituent.Some strains also showed a dependence on the presence of heteroatoms (O, N, S) in the N1 group.No significant correlations between gyrase inhibition and correlations of these parameters were found.These QSAR results are discussed in conjunction with the conformational analyses from molecular modeling studies.The substituent that most enhanced the activity of the quinolone in all regards was the cyclopropyl group.This analogue, 1-cyclopropyl-7--1-pyrrolidinyl>-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid (PD 117558), demonstrated outstanding broad spectrum activity both in vitro and in vivo when compared to relevant standards.

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