113225-07-3

Basic information

• Product Name: 1,2,3,6-TETRAHYDRO-1-METHYL-4-(2,4,6-TRIMETHOXYPHENYL)-PYRIDINE
• Synonyms: 1,2,3,6-TETRAHYDRO-1-METHYL-4-(2,4,6-TRIMETHOXYPHENYL)-PYRIDINE;1-METHYL-4-(2,4,6-TRIMETHOXYPHENYL)-1,2,3,6-TETRAHYDROPYRIDINE;PYRIDINE, 1,2,3,6-TETRAHYDRO-1-METHYL-4-(2,4,6-TRIMETHOXYPHENYL)-
• CAS NO: 113225-07-3
• Molecular Formula: C₁₅H₂₁NO₃
• Molecular Weight: 263.33
• Mol File: 113225-07-3.mol
• Article Data: 13

Chemical Properties

• Boiling Point: 395.4°Cat760mmHg
• Flash Point: 117.9°C
• Appearance: /
• Density: 1.074g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.528
• CAS DataBase Reference: 1,2,3,6-TETRAHYDRO-1-METHYL-4-(2,4,6-TRIMETHOXYPHENYL)-PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,3,6-TETRAHYDRO-1-METHYL-4-(2,4,6-TRIMETHOXYPHENYL)-PYRIDINE(113225-07-3)
• EPA Substance Registry System: 1,2,3,6-TETRAHYDRO-1-METHYL-4-(2,4,6-TRIMETHOXYPHENYL)-PYRIDINE(113225-07-3)

Safety Data

• Hazardous Substances Data: 113225-07-3(Hazardous Substances Data)

Usage

General Description

1,2,3,6-Tetrahydro-1-methyl-4-(2,4,6-trimethoxyphenyl)-pyridine is a chemical compound with the molecular formula C18H25NO3. It is a derivative of pyridine and is commonly used in the pharmaceutical industry as a potential drug candidate for the treatment of various conditions. The compound is known for its unique structure, which includes a tetrahydropyridine ring and multiple methoxy groups attached to the phenyl ring. This chemical compound has attracted attention due to its potential medicinal properties, and ongoing research is exploring its potential applications in the field of medicine.

InChI:InChI=1/C15H21NO3/c1-16-7-5-11(6-8-16)15-13(18-3)9-12(17-2)10-14(15)19-4/h5,9-10H,6-8H2,1-4H3

Upstream product

• 1445-73-4 1-Methyl-4-piperidone 
• 621-23-8 1,2,3-trimethoxybenzene 

Downstream Products

• 113225-08-4 cis-1-methyl-4-(2,4,6-trimethoxyphenyl)-3-piperidinol 
• 113225-10-8 (+)-1-Methyl-4-(2,4,6-trimethoxyphenyl)-piperidin-3-one 
• 117955-09-6 (±)-trans-[1-methyl-3-(2,4,6-trimethoxyphenyl)pyrrolidin-2-yl]methanol 
• 872057-13-1 1-(2-hydroxy-4,6-dimethoxy-3-(1-methylpiperidin-4-yl)phenyl)ethanone 
• 916888-58-9 2-acetyl-3,5-dimethoxy-6-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)phenyl 3-chlorobenzoate 
• 916888-59-0 2-acetyl-3,5-dimethoxy-6-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)phenyl 4-chlorobenzoate 
• 916888-57-8 2-acetyl-3,5-dimethoxy-6-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)phenyl 2-chlorobenzoate 
• 916888-61-4 2-(4-chlorophenyl)-5,7-dimethoxy-8-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-4H-benzopyran-4-one 
• 190973-27-4 2-(3-chlorophenyl)-5,7-dimethoxy-8-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-4H-benzopyran-4-one 
• 190972-89-5 2-(2-chlorophenyl)-5,7-dimethoxy-8-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-4H-benzopyran-4-one 
• 916888-60-3 2-acetyl-3,5-dimethoxy-6-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)phenyl benzoate 
• 916888-62-5 2-phenyl-5,7-dimethoxy-8-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)-4H-benzopyran-4-one 
• 872057-12-0 1-(N-methylpiperidin-4-yl)-2,4,6-trimethoxybenzene 
• 113225-08-4 (±)-trans-1-methyl-4-(2,4,6-trimethoxyphenyl)piperidin-3-ol 

Relevant articles and documents

Piperidinyl-embeded chalcones possessing anti PI3Kδ inhibitory properties exhibit anti-atopic properties in preclinical models

Phosphatidylinositide 3-kinases (PI3Ks) are widely expressed enzymes involved in membrane signalization pathways. Attempts to administer inhibitors with broad activity against different isoforms have failed due to toxicity. Conversely the PI3Kδ isoform is

Synthesis of newer piperidinyl chalcones and their anticancer activity in human cancer cell lines

Newer tetrahydropyridine chalcones were synthesized and tested for their antioxidant and anticancer activity. These molecules showed significant anticancer activity at IC50 50 μM in human cancer cell lines such as A549 (lung adenocarcinoma),

A PROCESS FOR PREPARATION OF AN INTERMEDIATE OF THE PYRROLIDINE SUBSTITUTED FLAVONES

The present invention relates to a process for the preparation of a key intermediate (as described herein) used in the synthesis of (+)-trans enantiomer of pyrrolidine substituted flavones, represented by the compounds of formula (1) or pharmaceutically a