113225-14-2Relevant academic research and scientific papers
4H-1-benzopyran-4-one compounds which have anti-inflamatory or immunodulating action
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, (2008/06/13)
The present invention relates to novel 4H-1-benzopyran-4-one derivatives, to processes for the preparation thereof and to their use as anti-inflammatory, analgesic, immuno-suppressive and anti-allergic agents. In particular, the present invention relates to novel compounds of the formula I, STR1 in which R1 is hydrogen, alkyl having 1 to 6 carbon atoms, arly-C1 -C4 -alkyl, substituted C1 -C6 -alkyl, C3 -C6 -cycloalkyl, C3 -C6 -cycloalkyl-C1 -C4 -alkyl, C2 -C6 -alkenyl, C3 -C6 -alkynyl, aryl or carboxyl or an aldehyde or COO--C1 -C4 -alkyl group, R2 is hydrogen, alkyl having 1 to 6 carbon atoms, nitro, amino, di-C1 -C4 -alkylamino or a halogen, R3 is C1 -C4 -alkyl, substituted C1 -C4 -alkyl, hydroxyl, C1 -C4 -alkoxy, aryl-C1 -C4 -alkyl, nitro, amino, a C1 -C4 -alkylamino or di-C1 -C4 -alkylamino group or halogen, R4 is hydrogen, hydroxyl, C1 -C4 -alkyoxy, C1 -C4 -alkyoxycarbonyl, aryloxy, amino or a C1 -C4 -alkylamino or di-C1 -C4 -alkylamino group, R5 is hydrogen, C1 -C6 -alkyl, substituted C1 -C6 -alkyl, aryl-C1 -C4 -alkyl, C3 -C6 -cycloalkyl, C3 -C6 -cycloalkyl-C1 -C4 -alkyl, C1 -C4 -alkanoyl or aroyl, the aryl group being phenyl which is unsubstituted, monosubstituted or polysubstituted, m is an integer between 0 and 3 and n is an integer between 0 and 2, and to pharmacologically acceptable acid addition salts thereof.
AN ANTIINFLAMMATORY CUM IMMUNOMODULATORY PIPERIDINYLBENZOPYRANONE FROM DYSOXYLUM BINECTARIFERUM : ISOLATION, STRUCTURE AND TOTAL SYNTHESYS
Naik, Ramachandra G.,Kattige, S. L.,Bhat, S. V.,Alreja, B.,Souza, N. J. de,Rupp, R. H.
, p. 2081 - 2086 (2007/10/02)
(+)-cis-5,7-dihydroxy-methyl-8--benzopyran-4-one was identified as the antiinflammatory cum immunmodulatory principle of the stem bark of Dysoxylum binectariferum.The sequence devised for its total synthesis was also use
