113239-16-0Relevant academic research and scientific papers
Design, Synthesis, and Testing of Potential Antisickling Agents. 7. Ethacrynic Acid Analogues
Abraham, D. J.,Mehanna, A. S.,Williams, F. S.,Cragoe, E. J.,Woltersdorf, O. W.
, p. 2460 - 2467 (2007/10/02)
In search of a drug to treat sickle cell anemia, several analogues of the diuretic ethacrynic acid (ECA) have been synthesized and found equivalent in antigelling potency to ECA, but they have moderate or little diuretic activity.Structure-activity studie
Compounds useful in treating sickle cell anemia
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, (2008/06/13)
The present invention is directed to compounds of the general formula I and pharmaceutically acceptable salts thereof: STR1 wherein R=H or lower alkyl; R'=H, lower alkyl, benzyl, CH2 OH; A=(CH2)1 to 5, >C(CH3)s
[1-Oxo-2-halo(or hydrogen) indanyloxy]-alkanoic acid
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, (2008/06/13)
[1-Oxo-2-halo(or hydrogen)indanyloxy(or thio)]-alkanoic acid products and salts, esters and amide derivatives where the indanyl ring may be further substituted with from 2 to 5 nuclear substituents. The [1-oxo-2-haloindanyloxy-(or thio)]alkanoic acids are prepared (1) via the halogenation of a [1-oxoindanyloxy(or thio)]alkanoic acid or (2) via the addition of halogen to a [1-oxoindenyloxy(or thio)]-alkanoic acid. The [1-oxoindanyloxy(or thio)]alkanoic acids are prepared (1) via cyclialkylation of a (2-alkylideneacyl)-phenoxy(or thio)alkanoic acid or (2) via etherification of a hydroxy(or mercapto)-2-alkyl-1-indanone. The [1-oxo-2-halo(or hydrogen)indanyloxy(or thio)]alkanoic acids are diuretics and saluretics. In addition, some of these compounds are also able to maintain the uric acid concentration in the body at pretreatment level or to cause a decrease in uric acid concentration.
