113248-59-2Relevant academic research and scientific papers
Discovery of allosteric potentiators for the metabotropic glutamate 2 receptor: Synthesis and subtype selectivity of N-(4-(2-methoxyphenoxy)phenyl)-N-(2,2,2-trifluoroethylsulfonyl)pyrid-3- ylmethylamine
Johnson, Michael P.,Baez, Melvyn,Jagdmann Jr., G. Erik,Britton, Thomas C.,Large, Thomas H.,Callagaro, David O.,Tizzano, Joseph P.,Monn, James A.,Schoepp, Darryle D.
, p. 3189 - 3192 (2003)
This report describes recently discovered novel allosteric modulators of metabotropic glutamate2 (mGlu2) receptors. These pyridylmethylsulfonamides (e.g., 3) potentiate glutamate, shifting agonist potency by 2-fold. This effect was specific for mGlu2 (vs
Potentiators of glutamate receptors
-
Page 34-35, (2010/02/05)
The present invention relates to potentiators of metabotropic glutamate receptor function and specifically provides compounds of formula I, compositions thereof and methods of using the same.
