113250-75-2 Usage
Class
Diaryl-substituted heteroaryl acetic acids
Use
Nonsteroidal anti-inflammatory drug (NSAID) for the treatment of inflammation and pain
Mechanism
Inhibits the synthesis of prostaglandins involved in the inflammatory response
Administration
Often used topically in the form of eye drops for postoperative ocular pain and inflammation
Effectiveness
Reduces inflammation and increases patient comfort following cataract surgery
Adverse effects
May cause eye irritation or increased risk of bleeding
Caution
Should be used under the supervision of a healthcare professional
Check Digit Verification of cas no
The CAS Registry Mumber 113250-75-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,3,2,5 and 0 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 113250-75:
(8*1)+(7*1)+(6*3)+(5*2)+(4*5)+(3*0)+(2*7)+(1*5)=82
82 % 10 = 2
So 113250-75-2 is a valid CAS Registry Number.
113250-75-2Relevant articles and documents
Benzyne Cyclization Route to Benzophenanthridine Alkaloids. Synthesis of Chelerythrine, Decarine, and Nitidine
Kessar, Satinder V.,Gupta, Yash P.,Balakrishnan, Prasanna,Sawal, Kewal K.,Mohammad, Taj,Dutt, Mahesh
, p. 1708 - 1713 (2007/10/02)
The alkaloids chelerythrine (8b) and decarine (7c) have been synthesized through a benzyne-mediated cyclization of N-(2-halobenzyl)-1-naphthylamines 4 with KNH2 in ammonia/ether.The 7-hydroxybenzophenanthridine structure 16a proposed for the alkaloid fagaridine is questioned on the basis of comparison with a model compound (16b) synthesized by benzyne cyclization.For the 8,9-oxygenated alkaloids like nitidine (8i), this cyclization proceeded poorly, but a dramatic improvement occurred when LDA/THF at -78 deg C was used instead of KNH2/NH3.
