1132609-89-2Relevant academic research and scientific papers
2-(6-Phenyl-1H-indazol-3-yl)-1H-benzo[d]imidazoles: Design and synthesis of a potent and isoform selective PKC-ζ inhibitor
Trujillo, John I.,Kiefer, James R.,Huang, Wei,Thorarensen, Atli,Xing, Li,Caspers, Nicole L.,Day, Jacqueline E.,Mathis, Karl J.,Kretzmer, Kuniko K.,Reitz, Beverley A.,Weinberg, Robin A.,Stegeman, Roderick A.,Wrightstone, Ann,Christine, Lori,Compton, Robert,Li, Xiong
scheme or table, p. 908 - 911 (2009/09/06)
The inhibition of PKC-ζ has been proposed to be a potential drug target for immune and inflammatory diseases. A series of 2-(6-phenyl-1H indazol-3-yl)-1H-benzo[d]imidazoles with initial high crossover to CDK-2 has been optimized to afford potent and selec
