1132610-54-8Relevant articles and documents
2-Aminoimidazoles inhibitors of TGF-β receptor 1
Bonafoux, Dominique,Chuaqui, Claudio,Boriack-Sjodin, P. Ann,Fitch, Chris,Hankins, Gretchen,Josiah, Serene,Black, Cheryl,Hetu, Gregg,Ling, Leona,Lee, Wen-Cherng
scheme or table, p. 912 - 916 (2009/10/15)
The 4-(5-fluoro-6-methyl-pyridin-2-yl)-5-quinoxalin-6-yl-1H-imidazol-2-ylamine 3 is a potent and selective inhibitor of TGF-βR1. Substitution of the amino group of 3 typically led to a slight decrease in the affinity for the receptor and in TGF-β-inducted