1132610-60-6 Usage
General Description
Phosphonic acid, P-[(5-fluoro-6-Methyl-2-pyridinyl)(phenylamino)methyl]-, diphenyl ester is a chemical compound commonly used as a fungicide and herbicide. It belongs to the class of phosphonates, which are organic compounds containing a phosphorus atom attached to oxygen atoms and alkyl or aryl groups. This particular compound consists of a phosphonic acid core with a diphenyl ester attached to it, as well as a pyridine and phenylamino substituent. It is often used in agricultural applications to protect crops from fungal and weed infestations, and its structure allows for strong and selective inhibition of fungal and plant growth. However, it is important to handle this chemical with caution, as it can be harmful if ingested or inhaled, and precautions should be taken to avoid environmental contamination.
Check Digit Verification of cas no
The CAS Registry Mumber 1132610-60-6 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,3,2,6,1 and 0 respectively; the second part has 2 digits, 6 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 1132610-60:
(9*1)+(8*1)+(7*3)+(6*2)+(5*6)+(4*1)+(3*0)+(2*6)+(1*0)=96
96 % 10 = 6
So 1132610-60-6 is a valid CAS Registry Number.
1132610-60-6Relevant articles and documents
Synthesis and biological evaluation of 5-(fluoro-substituted-6-methylpyridin-2-yl)-4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)imidazoles as inhibitors of transforming growth factor-β type i receptor kinase
Krishnaiah, Maddeboina,Jin, Cheng Hua,Sheen, Yhun Yhong,Kim, Dae-Kee
supporting information, p. 5228 - 5231 (2015/11/09)
To further optimize a clinical candidate 5 (EW-7197), a series of 5-(3-, 4-, or 5-fluoro-substituted-6-methylpyridin-2-yl)-4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)imidazoles 19a-l have been synthesized and evaluated for their TGF-β type I receptor kinase (ALK5) and p38α MAP kinase inhibitory activity in an enzyme assay. The 5-(5-fluoro-substituted-6-methylpyridin-2-yl)-4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)imidazoles 19h-l displayed the similar level of potency to that of 5 against both ALK5 (IC50 = 7.68-13.70 nM) and p38α MAP kinase (IC50 = 1240-3370 nM). Among them, 19j inhibited ALK5 with IC50 value of 7.68 nM in a kinase assay and displayed 82% inhibition at 100 nM in a luciferase reporter assay.
