113262-76-3Relevant academic research and scientific papers
Design, Synthesis, and Testing of Potential Antisickling Agents. 7. Ethacrynic Acid Analogues
Abraham, D. J.,Mehanna, A. S.,Williams, F. S.,Cragoe, E. J.,Woltersdorf, O. W.
, p. 2460 - 2467 (2007/10/02)
In search of a drug to treat sickle cell anemia, several analogues of the diuretic ethacrynic acid (ECA) have been synthesized and found equivalent in antigelling potency to ECA, but they have moderate or little diuretic activity.Structure-activity studie
Compounds useful in treating sickle cell anemia
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, (2008/06/13)
The present invention is directed to compounds of the general formula I and pharmaceutically acceptable salts thereof: STR1 wherein R=H or lower alkyl; R'=H, lower alkyl, benzyl, CH2 OH; A=(CH2)1 to 5, >C(CH3)s
