1132652-30-2Relevant academic research and scientific papers
Synthesis of (-)-mitrephorone A via a bioinspired late stage C-H oxidation of (-)-mitrephorone B
Wein, Lukas Anton,Wurst, Klaus,Angyal, Peter,Weisheit, Lara,Magauer, Thomas
supporting information, p. 19589 - 19593 (2019/12/25)
We present a bioinspired late-stage C-H oxidation of the ent-trachylobane natural product mitrephorone B to mitrephorone A. The realization of this unprecedented transformation was accomplished by either an iron-catalyzed or electrochemical oxidation and enabled access to the densely substituted oxetane in one step. Formation of mitrephorone C, which is lacking the central oxetane unit but features a keto-function at C2, was not formed under these conditions.
