1132656-41-7Relevant academic research and scientific papers
Octahydrophenanthrene-2,7-diol Analogues as dissociated glucocorticoid receptor agonists: Discovery and lead exploration
Robinson, Ralph P.,Buckbinder, Leonard,Haugeto, Amber I.,McNiff, Patricia A.,Millham, Michele L.,Reese, Matthew R.,Schaefer, Jean F.,Abramov, Yuriy A.,Bordner, Jon,Chantigny, Yves A.,Kleinman, Edward F.,Laird, Ellen R.,Morgan, Bradley P.,Murray, John C.,Salter, Eben D.,Wessel, Matthew D.,Yocum, Sue A.
experimental part, p. 1731 - 1743 (2010/03/01)
As exemplified by the lead compound 2, octahydrophenanthrene-2,7-diol analogues exhibit the profile of a pathway-selective or "dissociated" agonist of the glucocorticoid receptor (GR), retaining the potent activity that glucocorticoids have for transrepre
