1132656-73-5

Basic information

• Product Name: (R)-Ostarine
• Synonyms: (R)-Ostarine;(R)-N-(4-Cyano-3-(trifluoroMethyl)phenyl)-3-(4-cyanophenoxy)-2-hydroxy-2-MethylpropanaMide;(R)-3-(4-Cyanophenoxy)-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropionamide
• CAS NO: 1132656-73-5
• Molecular Formula: C₁₉H₁₄F₃N₃O₃
• Molecular Weight: 389.3279696
• Product Categories: Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 1132656-73-5.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 632.3±55.0 °C(Predicted)
• Appearance: /
• Density: 1.41±0.1 g/cm3(Predicted)
• Storage Temp.: -20°C Freezer
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 12.13±0.29(Predicted)
• BRN: 21172990
• CAS DataBase Reference: (R)-Ostarine(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-Ostarine(1132656-73-5)
• EPA Substance Registry System: (R)-Ostarine(1132656-73-5)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 1132656-73-5(Hazardous Substances Data)

Usage

Chemical Properties

Pale Yellow to Light Orange Solid

Uses

The R-enantiomer of nonsteroidal selective androgen receptor modulator (SARM) Ostarine (O703500).

Upstream product

• 767-00-0 4-cyanophenol 
• 113181-02-5 (S)-(-)-3-bromo-2-hydroxy-2-methyl-N-[(4-cyano-3-(trifluoromethyl)phenyl)]propanamide 

Relevant articles and documents

Synthetic method of alpha-hydroxypropanamide derivatives with optical activity

The invention discloses a synthetic method of alpha-hydroxypropanamide derivatives with optical activity and belongs to the field of organic synthesis. Proline taken as a chiral auxiliary, as well asmethacryloyl chloride, is subjected to acylation, bromination and chiral auxiliary removal, a product and 4-cyano-3-trifluoromethylaniline are subjected to nucleophilic substitution, and 3-bromo-2-hydroxy-2-methyl-N-[(4-cyano-3-trifluoromethyl)phenyl]propanamide is obtained and subjected to nucleophilic substitution with 4-cyanophenol, and the compound 3-(4-cyanophenoxy)-N-[4-cyano-3-(trifluoromethylphenyl]-2-hydroxy-2-methylpropanamide with optical activity is prepared. 3-bromo-2-hydroxy-2-methyl propionic acid and 4-nitro-3-trifluoromethylaniline are subjected to aminolysis, a product is subjected to nucleophilic substitution with paracetamol, and the compound 3-(4-acetoxyphenoxy)-N-[4-nitro-3-(trifluoromethylphenyl]-2-hydroxy-2-methylpropanamide with optical activity is prepared. The efficient synthetic method of the alpha-hydroxypropanamide derivatives with optical activity is provided.