1132666-99-9Relevant academic research and scientific papers
Efficient synthesis of (R)-3-amino-1,1,1-trifluoropropan-2-ol via a Dakin-West reaction followed by enantioselective reduction
Wei, Lulin,Makowski, Teresa,Martinez, Carlos,Ghosh, Arun
, p. 2648 - 2651 (2008)
An efficient, chromatography-free asymmetric synthesis of (R)-3-amino-1,1,1-trifluoropropan-2-ol was developed for large scale production of a cholesterol ester transfer protein (CETP) inhibitor. The synthesis features a new efficient route to a β-amino trifluoromethylketone involving a modified Dakin-West reaction followed by an asymmetric hydrogenation or an enzymatic reduction of the resulting ketone to the alcohol.
