1132675-19-4Relevant academic research and scientific papers
Synthesis of riccardin C and its seven analogues. Part 1: The role of their phenolic hydroxy groups as LXRα agonists
Hioki, Hideaki,Shima, Naoki,Kawaguchi, Kota,Harada, Kenich,Kubo, Miwa,Esumi, Tomoyuki,Nishimaki-Mogami, Tomoko,Sawada, Jun-ichi,Hashimoto, Toshihiro,Asakawa, Yoshinori,Fukuyama, Yoshiyasu
scheme or table, p. 738 - 741 (2009/12/03)
Riccardin C, a nuclear receptor LXRα selective agonist, is an 18-membered macrocyclic bisbibenzyl isolated from several liverworts. Synthesis of riccardin C and its seven O-methylated derivatives was accomplished. The synthetic sequence highlights an intramolecular Suzuki-Miyaura coupling in the formation of the 18-membered biaryl linkage present in riccardin C. The structure-activity relationship of these compounds suggests that all of the phenolic hydroxy groups present in riccardin C are essential for the activation of LXRα.
