113269-03-7

Basic information

• Product Name: 1,2-DITOSYLAMINO-4-FLUORO-5-NITROBENZENE
• Synonyms: N1-(4-FLUORO-2-([(4-METHYLPHENYL)SULFONYL]AMINO)-5-NITROPHENYL)-4-METHYLBENZENE-1-SULFONAMIDE;1,2-DITOSYLAMINO-4-FLUORO-5-NITROBENZENE;1,2-Ditosylamino-4-fluoro-5-nitrobenzene,Tech
• CAS NO: 113269-03-7
• Molecular Formula: C₂₀H₁₈FN₃O₆S₂
• Molecular Weight: 479.5
• Product Categories: pharmacetical
• Mol File: 113269-03-7.mol

Chemical Properties

• Boiling Point: 630.1°Cat760mmHg
• Flash Point: 334.9°C
• Appearance: /
• Density: 1.516g/cm³
• Vapor Pressure: 8.69E-16mmHg at 25°C
• Refractive Index: 1.658
• PKA: 5.32±0.10(Predicted)
• CAS DataBase Reference: 1,2-DITOSYLAMINO-4-FLUORO-5-NITROBENZENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-DITOSYLAMINO-4-FLUORO-5-NITROBENZENE(113269-03-7)
• EPA Substance Registry System: 1,2-DITOSYLAMINO-4-FLUORO-5-NITROBENZENE(113269-03-7)

Safety Data

• Hazardous Substances Data: 113269-03-7(Hazardous Substances Data)

Usage

Common Use

Synthesis and organic chemistry

Type

Chemical compound

Derivative of

Nitrobenzene

Attached groups

Two tosylamino groups and one fluorine atom

Molecular Weight

369.32 g/mol

Applications

Reagent in the preparation of various organic compounds, production of pharmaceuticals and agrochemicals

Field of Use

Chemistry and chemical engineering

Versatility

Wide range of potential applications

InChI:InChI=1/C20H18FN3O6S2/c1-13-3-7-15(8-4-13)31(27,28)22-18-11-17(21)20(24(25)26)12-19(18)23-32(29,30)16-9-5-14(2)6-10-16/h3-12,22-23H,1-2H3

Upstream product

• 367-31-7 4-fluoro-1,2-phenylenediamine 
• 98-59-9 p-toluenesulfonyl chloride 
• 364-78-3 2-nitro-4-fluoroaniline 
• 113269-02-6 N,N'-(4-fluoro-1,2-phenylene)bis(4-methylbenzenesulfonamide) 

Downstream Products

• 113269-08-2 6-fluoro-7-nitroquinoxaline 
• 113269-06-0 4-fluoro-5-nitrobenzene-1,2-diamine 

Relevant articles and documents

Sulfonamide-based compounds as protein tyrosine kinase inhibitors

Various sulfonamide-based compounds are able to selectively inhibit the Src family of tyrosine kinases. These compounds are useful in the treatment of various diseases including hyperproliferative diseases, hematologic diseases, osteoporosis, neurological diseases, autoimmune diseases, allergic/immunological diseases, or viral infections.

THE FOUR 6-HALO-7-NITROQUINOXALINES

The study of relative nucleofugicities of nitro and halogen in quinoxalines required the synthesis of the four 6-halo-7-nitroquinoxalines 2a-d.The fluoro-, chloro- and bromo-derivatives were made from the commercially available or readily accessible 1,2-diamino-4-halobenzenes, using the nitration of the corresponding p-toluenesulfonamides.This scheme failed in the case of the iodo compound because of extensive nitro-deiodination.The synthesis of 6-iodo-7-nitroquinoxaline was finally achieved from m-fluoroiodobenzene by taking advantage of the high reactivity of fluorine, compared to iodine, in 2,4-dinitrohalobenzenes.