1132706-07-0

Usage

Also known as

4-Chloro-α-methylphenylglycine amide

Physical form

white to off-white solid

Use

pharmaceutical research as a potential intermediate in the synthesis of biologically active compounds

Classification

amide

Contains

amino group, carboxylic acid group, phenyl ring with a chlorine substituent

Health hazards

potential health hazards, requires proper handling and protective equipment

Upstream product

• 56-41-7 L-alanin 
• 106-47-8 4-chloro-aniline 
• 179683-44-4 (-)-(S)-N²-(tert-butoxycarbonyl)-N¹-(4-chlorophenyl)alaninamide 

Relevant academic research and scientific papers

New sulphonamide pyrolidine carboxamide derivatives: Synthesis, molecular docking, antiplasmodial and antioxidant activities

Carboxamides bearing sulphonamide functionality have been shown to exhibit significant lethal effect on Plasmodium falciparum, the causative agent of human malaria. Here we report the synthesis of thirty-two new drug-like sulphonamide pyrolidine carboxami

Compound and application thereof

The invention provides a novel compound. The novel compound has certain inhibitory activity for indoleamine 2,3-dioxygenase (IDO) which is oxido-reductase, and accordingly the novel compound can be used for treating diseases related to the indoleamine 2,3-dioxygenase and can be applied to cancer and immunity related diseases.

Amino Acid Amide based Ionic Liquid as an Efficient Organo-Catalyst for Solvent-free Knoevenagel Condensation at Room Temperature

Abstract: Ionic liquids of amino acid amide were synthesized and used as an efficient catalyst for solvent-free Knoevenagel condensation. Synthesized ionic liquids are an environmentally benign, inexpensive, metal free and plays the dual role of solvent as well as an efficient catalyst for Knoevenagel condensation. A wide range of aliphatic, aromatic and heteroaromatic aldehydes easily undergo condensation with malononitrile and ethyl cyanoacetate. The reaction proceeds at room temperature without using any organic solvent and is very fast with good to excellent yield. Additionally, the catalyst is easily separable and recyclable without loss of activity. Graphic Abstract: [Figure not available: see fulltext.].

Cinnamamide compound, and salt, intermediate preparation method and application thereof

The invention discloses a cinnamamide compound as shown in a formula A which is defined in the specification, and a pharmaceutically acceptable salt thereof. The invention also discloses a preparation method, intermediate and application of the cinnamamide compound. The compound is a histone deacetylase inhibitor and is applicable to pharmaceutical compositions with antineoplastic effect.

Discovery of potent and selective phenylalanine derived CCR3 receptor antagonists. Part 2

Highly potent CCR3 antagonists have been developed from a previously reported series of phenylalanine ester-based leads. Solution-phase, parallel synthesis optimization was utilized to identify highly potent, functional CCR3 antagonists.