Ropinirole-d14 HCl, also known as di-n-propyl-d14, is an isotopically labeled research compound with the CAS number 1132746-05-4. It is a deuterated form of Ropinirole, a non-ergoline dopamine agonist used in the treatment of Parkinson's disease and restless legs syndrome. The incorporation of deuterium isotopes in Ropinirole-d14 HCl allows for enhanced stability and longer half-life, making it a valuable tool in scientific research and drug development.
1132746-05-4
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Basic information
- Product Name: Ropinirole-d14 HCl
- Synonyms: Ropinirole-d14 HCl
- CAS NO:1132746-05-4
- Molecular Formula: C16H10D14N2O
- Molecular Weight: 274.460824892
- EINECS: N/A
- Product Categories: N/A
- Mol File: 1132746-05-4.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: N/A
- Solubility: N/A
- CAS DataBase Reference: Ropinirole-d14 HCl(CAS DataBase Reference)
- NIST Chemistry Reference: Ropinirole-d14 HCl(1132746-05-4)
- EPA Substance Registry System: Ropinirole-d14 HCl(1132746-05-4)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 1132746-05-4(Hazardous Substances Data)
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1132746-05-4 Usage
Uses
Used in Pharmaceutical Research:Ropinirole-d14 HCl is used as a research compound for studying the pharmacokinetics, metabolism, and mechanism of action of Ropinirole in various biological systems. Its deuterated nature provides a distinct advantage in mass spectrometry and nuclear magnetic resonance (NMR) studies, enabling researchers to differentiate between the parent compound and its metabolites, thus facilitating a better understanding of its biotransformation pathways.
Used in Drug Development:
In the field of drug development, Ropinirole-d14 HCl serves as a valuable tool for assessing the safety, efficacy, and pharmacological properties of Ropinirole. Its isotopically labeled nature allows for the investigation of potential drug-drug interactions, off-target effects, and the development of personalized medicine strategies based on individual metabolic profiles.
Used in Neurological Disorders Research:
Ropinirole-d14 HCl is employed as a research compound in the study of neurological disorders such as Parkinson's disease and restless legs syndrome. Its deuterated form enables researchers to investigate the underlying molecular mechanisms, identify potential biomarkers, and develop novel therapeutic approaches for these conditions.
Used in Radioligand Binding Assays:
In radioligand binding assays, Ropinirole-d14 HCl is used as a reference compound to determine the binding affinity and selectivity of Ropinirole for specific dopamine receptors. This information is crucial for understanding the therapeutic potential of Ropinirole and its analogs in the treatment of various neurological and psychiatric disorders.
Used in Mass Spectrometry and NMR Studies:
Ropinirole-d14 HCl is utilized in mass spectrometry and NMR studies to investigate the structural and conformational properties of Ropinirole and its analogs. The deuterium labeling provides a unique signature that allows for the differentiation between the compound of interest and other similar molecules, facilitating the elucidation of its molecular interactions and dynamics.
Check Digit Verification of cas no
The CAS Registry Mumber 1132746-05-4 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,3,2,7,4 and 6 respectively; the second part has 2 digits, 0 and 5 respectively.Calculate Digit Verification of CAS Registry Number 1132746-05:
(9*1)+(8*1)+(7*3)+(6*2)+(5*7)+(4*4)+(3*6)+(2*0)+(1*5)=124
124 % 10 = 4
So 1132746-05-4 is a valid CAS Registry Number.
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1132746-05-4Downstream Products
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Ropinirole-d14 HCl
