1132798-01-6

Basic information

• Product Name: C₂₁H₂₁N₅O₆S₂
• Synonyms: C₂₁H₂₁N₅O₆S₂
• CAS NO: 1132798-01-6
• Molecular Weight: 503.56
• Mol File: 1132798-01-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₁H₂₁N₅O₆S₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₁H₂₁N₅O₆S₂(1132798-01-6)
• EPA Substance Registry System: C₂₁H₂₁N₅O₆S₂(1132798-01-6)

Safety Data

• Hazardous Substances Data: 1132798-01-6(Hazardous Substances Data)

Upstream product

• 83673-98-7 2-[[(tert-butoxy)carbonyl]amino]-1,3-thiazole-4-carboxylic acid 

Relevant articles and documents

Discovery of inhibitors of aberrant gene transcription from libraries ofdna binding molecules: Inhibition of LEF-1-mediated gene transcription and oncogenic transformation

The screening of a >9000 compound library of synthetic DNA binding molecules for selective binding to the consensus sequence of the transcription factor LEF-1 followed by assessment of the candidate compounds in a series of assays that characterized functional activity (disruption of DNA-LEF-1 binding) at the intended target and site (inhibition of intracellular LEF-1-mediated gene transcription) resulting in a desired phenotypic cellular change (inhibit LEF-1-driven cell transformation) provided two lead compounds: lefmycin-1 and lefmycin-2. The sequence of screens defining the approach assures that activity in the final functional assay may be directly related to the inhibition of gene transcription and DNA binding properties of the identified molecules. Central to the implementation of this generalized approach to the discovery of DNA binding small molecule inhibitors of gene transcription was (1) the use of a technically nondemanding fluorescent intercalator displacement (FID) assay for initial assessment of the DNA binding affinity and selectivity of a library of compounds for any sequence of interest, and (2) the technology usedto prepare a sufficiently large library of DNA binding compounds.