Angiopeptin, also known as linear lanreotide, is an impurity of Lanreotide (CAS 108736-35-2). It is a synthetic peptide derived from somatostatin, a naturally occurring hormone that inhibits the release of various hormones and growth factors. Angiopeptin has a molecular weight of approximately 4,000 Da and consists of 14 amino acid residues. It exhibits anti-angiogenic, anti-inflammatory, and anti-proliferative properties, making it a potential candidate for various therapeutic applications.
113294-82-9
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Basic information
- Product Name: angiopeptin
- Synonyms: 3-(2-Naphthalenyl)-D-alanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-valyl-L-cysteinyl-L-threoninamide;3-(2-Naphthyl)alanyl-cystinyl-tyrosyl-tryptophyl-lysyl-valyl-cystinyl-threonine amide;3-(2-Naphthyl)-D-Ala-Cys-Tyr-D-Trp-Lys-Val-Cys-Thr-nh2;D-Nal-Cys-Tyr-Trp-Lys-Val-Cys-Thr-nh2;L-Threoninamide, 3-(2-naphthalenyl)-D-alanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-valyl-L-cysteinyl-;(S)-6-amino-2-((R)-2-((S)-2-((R)-2-((R)-2-amino-3-(naphthalen-2-yl)propanamido)-3-mercaptopropanamido)-3-(4-hydroxyphenyl)propanamido)-3-(1H-indol-3-yl)propanamido)-N-((S)-1-(((R)-1-(((2S,3R)-1-amino-3-hydroxy-1-oxobutan-2-yl)amino)-3-mercapto-1-oxopropan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)hexanamide(WXG02269);(S)-6-amino-2-((R)-2-((S)-2-((R)-2-((R)-2-amino-3-(naphthalen-2-yl)propanamido)-3-mercaptopropanamido)-3-(4-hydroxyphenyl)propanamido)-3-(1H-indol-3-yl)propanamido)-N-((S)-1-(((R)-1-(((2S,3R)-1-amino-3-hydroxy-1-oxobutan-2-yl)amino)-3-mercapto-1-oxopropan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)hexanamide
- CAS NO:113294-82-9
- Molecular Formula: C54H71N11O10S2
- Molecular Weight: 1098.33924
- EINECS: N/A
- Product Categories: N/A
- Mol File: 113294-82-9.mol
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Chemical Properties
- Melting Point: N/A
- Boiling Point: 1502.5°Cat760mmHg
- Flash Point: 862.5°C
- Appearance: /
- Density: 1.324g/cm3
- Vapor Pressure: 0mmHg at 25°C
- Refractive Index: 1.641
- Storage Temp.: N/A
- Solubility: N/A
- PKA: 9.16±0.10(Predicted)
- CAS DataBase Reference: angiopeptin(CAS DataBase Reference)
- NIST Chemistry Reference: angiopeptin(113294-82-9)
- EPA Substance Registry System: angiopeptin(113294-82-9)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 113294-82-9(Hazardous Substances Data)
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113294-82-9 Usage
Uses
Used in Pharmaceutical Industry:Angiopeptin is used as an anti-angiogenic agent for inhibiting the formation of new blood vessels in tumors. It interferes with the binding of growth factors, such as vascular endothelial growth factor (VEGF) and fibroblast growth factor (FGF), to their receptors on endothelial cells, thereby preventing the proliferation and migration of these cells.
Used in Cancer Treatment:
Angiopeptin is used as an adjunct therapy in cancer treatment for reducing tumor growth and metastasis. It has been shown to be effective in various types of cancer, including colorectal, pancreatic, and lung cancer. It can be used in combination with other chemotherapeutic agents to enhance their anti-tumor effects and reduce side effects.
Used in Inflammatory Diseases:
Angiopeptin is used as an anti-inflammatory agent for treating various inflammatory conditions, such as rheumatoid arthritis, inflammatory bowel disease, and atherosclerosis. It inhibits the expression of pro-inflammatory cytokines and chemokines, reducing inflammation and tissue damage.
Used in Wound Healing:
Angiopeptin is used as a wound healing agent for promoting tissue repair and regeneration. It stimulates the production of growth factors, such as transforming growth factor-beta (TGF-β) and platelet-derived growth factor (PDGF), which are essential for tissue repair and remodeling.
Used in Drug Delivery Systems:
Angiopeptin can be used as a targeting moiety in drug delivery systems for improving the specificity and efficacy of therapeutic agents. It can be conjugated to nanoparticles, liposomes, or other drug carriers to enhance their accumulation in target tissues, such as tumors, and reduce off-target effects.
Used in Biological Research:
Angiopeptin is used in biological research for studying the molecular mechanisms of angiogenesis, inflammation, and cell proliferation. It can be employed as a tool compound to investigate the role of growth factors, their receptors, and downstream signaling pathways in various physiological and pathological processes.
Check Digit Verification of cas no
The CAS Registry Mumber 113294-82-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,3,2,9 and 4 respectively; the second part has 2 digits, 8 and 2 respectively.Calculate Digit Verification of CAS Registry Number 113294-82:
(8*1)+(7*1)+(6*3)+(5*2)+(4*9)+(3*4)+(2*8)+(1*2)=109
109 % 10 = 9
So 113294-82-9 is a valid CAS Registry Number.
InChI:InChI=1/C54H71N11O10S2/c1-3-10-40(49(70)64-45(29-77)54(75)65-46(30(2)66)47(57)68)59-50(71)41(15-8-9-22-55)60-52(73)43(26-35-27-58-39-14-7-6-13-37(35)39)62-51(72)42(25-31-17-20-36(67)21-18-31)61-53(74)44(28-76)63-48(69)38(56)24-32-16-19-33-11-4-5-12-34(33)23-32/h4-7,11-14,16-21,23,27,30,38,40-46,58,66-67,76-77H,3,8-10,15,22,24-26,28-29,55-56H2,1-2H3,(H2,57,68)(H,59,71)(H,60,73)(H,61,74)(H,62,72)(H,63,69)(H,64,70)(H,65,75)/t30-,38-,40+,41+,42+,43-,44+,45+,46+/m1/s1
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113294-82-9Related news
Allograft vasculopathyShort-term angiopeptin (cas 113294-82-9) therapy and the incidence of graft vessel disease after heart transplantation08/17/2019
BackgroundGraft vessel disease, the major limitation for long-term success after heart transplantation, is triggered by injury to the graft vessel endothelium, resulting in the expression of adhesion molecules, the migration of leukocytes into the graft, and the release of growth factors. Angiop...detailed
Early inhibition of myointimal proliferation by angiopeptin (cas 113294-82-9) after balloon catheter injury in the rabbit☆☆☆★08/15/2019
Purpose: Coronary artery restenosis after percutaneous transluminal angioplasty occurs in more than 40% of patients. Angiopeptin, a stable synthetic octapeptide analogue of somatostatin, attenuates accelerated coronary artery myointimal thickening in rabbit cardiac allografts and myointimal thic...detailed
Research paperInhibition of myointimal proliferation of the rat carotid artery by the peptides, angiopeptin (cas 113294-82-9) and BIM 23034☆08/13/2019
Proliferation of vascular smooth muscle is an early and major event in the formation of an atherosclerotic lesion. Here we report for the first time the inhibitory effects on myointimal proliferation of the rat carotid artery by a synthetic peptide, angiopeptin, and its closely related congener,...detailed
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