113308-76-2

Upstream product

• 121463-10-3 But-2-ynoic acid 2,4,4-trimethyl-3-vinyl-cyclohex-2-enyl ester 
• 113308-77-3 3-oxo-butyric acid 2,4,4-trimethyl-3-((E)-3-oxo-but-1-enyl)-cyclohex-2-enyl ester 

Downstream Products

• 64657-20-1 (+/-)-desacetyl forskolin 
• 114250-82-7 C₃₀H₃₉NO₉Se 
• 114250-72-5 Benzoic acid (1R,5S,6S,7S,8R)-8-hydroxy-2,2,6,8-tetramethyl-12-oxo-11-oxa-tricyclo[5.3.2.0^1,6]dodec-9-en-5-yl ester 
• 114250-65-6 (1S,4aR,8R,8aR)-8-Benzoyloxy-2,5,5,8a-tetramethyl-4-oxo-1,4,4a,5,6,7,8,8a-octahydro-naphthalene-1-carboxylic acid methyl ester 
• 114250-74-7 (1S,4aR,8R,8aR)-8-Benzoyloxy-2,5,5,8a-tetramethyl-4-oxo-1,4,4a,5,6,7,8,8a-octahydro-naphthalene-1-carboxylic acid 

Relevant academic research and scientific papers

Total synthesis of forskolin - Part I

A new total synthesis of forskolin 1 has been achieved and this note describes the synthesis of the transfused enone 18 as a key-intermediate. Key steps are: 1) the intramolecular Diels-Alder reaction of 17 to afford the tricyclic lactone 8 (48-56%); 2) a

A simple access to a forskolin precursor

Cyclization of acetoacetate of hydroxy-ionone 1 into lactone 2, a precursor of forskolin, is shown to occur in excellent yield using Cs2CO3 or Cs2CO3/K2CO3 mixture.