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113310-88-6

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  • Benzamide,3,5-dichloro-N-[[(2S)-1-ethyl-2-pyrrolidinyl]methyl]-2,6-dihydroxy-,hydrobromide (1:1)

    Cas No: 113310-88-6

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113310-88-6 Usage

Chemical Properties

Colorless to yellowish solid

Uses

S-(+)-O-Desmethylraclopride Hydrobromide is used for the improved synthesis of [11C]-raclopride, a PET dopamine D2 receptors radioligand.

Check Digit Verification of cas no

The CAS Registry Mumber 113310-88-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,3,3,1 and 0 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 113310-88:
(8*1)+(7*1)+(6*3)+(5*3)+(4*1)+(3*0)+(2*8)+(1*8)=76
76 % 10 = 6
So 113310-88-6 is a valid CAS Registry Number.

113310-88-6 Well-known Company Product Price

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  • Sigma

  • (D204)  S-(+)-O-Desmethylraclopride hydrobromide  solid, ≥98% (HPLC)

  • 113310-88-6

  • D204-5MG

  • 3,361.41CNY

  • Detail

113310-88-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name S-(+)-O-Desmethylraclopride hydrobromide

1.2 Other means of identification

Product number -
Other names 3,5-dichloro-N-[[(2S)-1-ethylpyrrolidin-2-yl]methyl]-2,6-dihydroxybenzamide,hydrobromide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:113310-88-6 SDS

113310-88-6Downstream Products

113310-88-6Relevant articles and documents

An improved synthesis of PET dopamine D2 receptors radioligand [11c]raclopride

Fei, Xiangshu,Mock, Bruce H.,DeGrado, Timothy R.,Wang, Ji-Quari,Glick-Wilson, Barbara E.,Sullivan, Michael L.,Hutchins, Gary D.,Zheng, Qi-Huang

, p. 1897 - 1907 (2004)

An improved synthesis of [11C]raclopride is reported. The precursor desmethyl-raclopride was synthesized from 3,5-dichloro-2,6-dimethoxybenzoic acid and (S)-(-)-2-aminoethyl-1-ethylpyrrolidine via a straight-forward, four-step synthetic approac

Synthesis of ω-Fluoroalkoxy and Alkoxy Derivatives of Raclopride: Evaluation as Radioligands for PET study of Cerebral Dopamine D2 Receptors

Banks, William R.,Moerlein, Stephen M.,Parkinson, David,Welch, Michael J.

, p. 150 - 173 (2007/10/03)

A series of analogues of the dopamine D2 receptor antagonist raclopride were evaluated as radiopharmaceuticals for positron emission tomography (PET). In vitro assays indicate that the D2 affinity of the ligands are descreased by replacement of the 2-methoxy group of raclopride with ω-fluoroalkoxy substituents, and increased by removal of the 6-hydroxy substituent. The 2-fluoroethoxy derivative of deshydroxy raclopride, [(S)-2-[(3,5)-dichloro-2-(2'-fluoroethoxy)benzamido)-methyl]-1-ethylpyrrolidine], exhibited a D2 affinity (Ki = 12nM) close to that of raclopride itself (Ki = 9.5 nM). A one-step radiosynthesis of the fluorine-18 labeled analogue of this ligand with specific radioactivity > 2 Ci/μmol and 35 percent radiochemical yield (decay-corrected) was developed; there was poor receptor-specific localization of this radioligand in vivo in rats, however. These results underscore the inadequacy of in vitro receptor assays as the sole screening test for PET radiopharmaceuticals. Future development of this series of ligands should emphasize placement of the fluorine-18 label at an aromatic site remote from the intramolecular hydrogen-bonding sites necessary for receptor-active conformations

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