113322-83-1Relevant academic research and scientific papers
Asymmetric Electrophilic Substitution on Phenols. 2. Enantio- and Diastereoselective Synthesis of o-Hydroxyatrolactic Esters
Casiraghi, Giovanni,Bigi, Franca,Casnati, Giuseppe,Sartori, Giovanni,Soncini, Paolo,et al.
, p. 1779 - 1785 (2007/10/02)
Both 2R and 2S stereoisomers of o-hydroxyatrolactic acid esters 3-5 are available with respective absolute configuration from phenols 1 and pyruvic acid esters 2 by using menthol only as a chiral inductor.Three asymmetric approaches were designed based on
HIGHLY STEREOCONTROLLED SUBSTITUTION OF PHENOLS WITH PYRUVIC ESTERS. A VIABLE ROUTE TO ortho-HYDROXYATROLACTIC ESTERS OF (2R)- AND (2S)-CONFIGURATION
Bigi, Franca,Casiraghi, Giovanni,Casnati, Giuseppe,Sartori, Giovanni,Soncini, Paolo,et al.
, p. 2021 - 2024 (2007/10/02)
Treatment of phenols with optically active (+)- and (-)-menthyl pyruvate assisted by Al(III)- or Ti(IV)-based promoters leads to the formation of ortho-hydroxyatrolactic esters of (2R)- and (2S)-configuration.The use of suitable menthol-based promoters au
