1133352-99-4

Basic information

• Product Name: C₂₉H₃₂O₁₄
• Synonyms: C₂₉H₃₂O₁₄
• CAS NO: 1133352-99-4
• Molecular Weight: 604.565
• Mol File: 1133352-99-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₉H₃₂O₁₄(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₉H₃₂O₁₄(1133352-99-4)
• EPA Substance Registry System: C₂₉H₃₂O₁₄(1133352-99-4)

Safety Data

• Hazardous Substances Data: 1133352-99-4(Hazardous Substances Data)

Upstream product

• 60-82-2 3-(4-Hydroxy-phenyl)-1-(2,4,6-trihydroxy-phenyl)-propan-1-on 
• 572-09-8 2,3,4,6-tetra-O-acetyl-α-D-glucopyranosyl bromide 

Downstream Products

• 4192-90-9 4'-(β-D-glucopyranosyloxy)-2',4”,6'-trihydroxydihydrochalcone 

Relevant articles and documents

Synthesis and biological evaluation of phloridzin analogs as human concentrative nucleoside transporter 3 (hCNT3) inhibitors

Nucleoside transporter inhibitors have potential therapeutic applications as anticancer, antiviral, cardioprotective and neuroprotective agents. Although quite a few potent inhibitors of the equilibrative nucleoside transporters are known, largely missing are the concentrative nucleoside transporter inhibitors. Phloridzin (3, Ki = 16.00 μM) is a known moderate inhibitor of the concentrative nucleoside transporters. We have synthesized and evaluated analogs of phloridzin at the hCNT3 nucleoside transporter. Within the series of synthesized analogs compound 16 (Ki = 2.88 μM), possessing a ribofuranose sugar unit instead of a glucopyranose as present in phloridzin, exhibited the highest binding affinity at the hCNT3 transporter. Phloridzin and compound 16 have also been shown to be selective for the hCNT3 transporter as compared with the hENT1 transporter. Compound 16 can serve as a new lead which after further modifications could yield selective and potent hCNT3 inhibitors.