113337-39-6

Basic information

• Product Name: Ethanone, 2,2-dichloro-1-(2-methylphenyl)- (9CI)
• Synonyms: Ethanone, 2,2-dichloro-1-(2-methylphenyl)- (9CI)
• CAS NO: 113337-39-6
• Molecular Formula: C₉H₈Cl₂O
• Molecular Weight: 203.06522
• Product Categories: ACETYLHALIDE
• Mol File: 113337-39-6.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Ethanone, 2,2-dichloro-1-(2-methylphenyl)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Ethanone, 2,2-dichloro-1-(2-methylphenyl)- (9CI)(113337-39-6)
• EPA Substance Registry System: Ethanone, 2,2-dichloro-1-(2-methylphenyl)- (9CI)(113337-39-6)

Safety Data

• Hazardous Substances Data: 113337-39-6(Hazardous Substances Data)

Upstream product

• 611-15-4 1-methyl-2-vinyl-benzene 
• 921845-62-7 3-(dimethylamino)-1-(2-tolyl)-2-propen-1-one 
• 766-47-2 1-ethynyl-2-methylbenzene 
• 118-90-1 ortho-methylbenzoic acid 
• 87-24-1 ethyl 2-methylbenzoate 
• 35276-81-4 3-oxo-3-(o-tolyl)propanenitrile 
• 577-16-2 2-Methylacetophenone 

Downstream Products

• 1588766-42-0 C₉H₁₀Cl₂O 
• 1588766-46-4 C₉H₁₀Cl₂O 
• 18067-50-0 C₉H₁₀Cl₂O 

Relevant articles and documents

Ultrasound-assisted tandem reaction of alkynes and trihaloisocyanuric acids by thiourea as catalyst in water

With water as the sole solvent, a green and efficient method has been developed for the synthesis of various α,α-dihaloketones via ultrasound assisted p-tolylthiourea catalyzed tandem reaction of alkynes with trihaloisocyanuric acids. This synthetic route

Method for preparing alpha,alpha-dichloroketone under solvent-free condition

The invention provides a method for synthesizing an alpha,alpha-dichloroketone compound by taking methyl ketone and sulfonyl chloride as raw materials. The method comprises the following steps: heating a reaction mixture of methyl ketone and sulfonyl chloride to 80 DEG C under a dry air condition, stirring for 4-8 hours, after the reaction is finished, removing sulfonyl chloride from the obtained mixture, and carrying out silica gel column chromatography separation by taking ethyl acetate-hexane as an eluent to obtain the alpha,alpha-dichloroketone compound. The synthesis method provided by the invention has the advantages of extremely high chemical reactivity and selectivity, simple and easily available raw materials, low price, simple operation, no need of any catalyst and solvent, reduction of the synthesis cost and the pollution of organic solvents to the environment, greenness, economy and the like.

Dichloroacetophenones targeting at pyruvate dehydrogenase kinase 1 with improved selectivity and antiproliferative activity: Synthesis and structure-activity relationships

Dichloroacetophenone is a pyruvate dehydrogenase kinase 1 (PDK1) inhibitor with suboptimal kinase selectivity. Herein, we report the synthesis and biological evaluation of a series of novel dichloroacetophenones. Structure-activity relationship analyses (SARs) enabled us to identify three potent compounds, namely 54, 55, and 64, which inhibited PDK1 function, activated pyruvate dehydrogenase complex, and reduced the proliferation of NCI-H1975 cells. Mitochondrial bioenergetics assay suggested that 54, 55, and 64 enhanced the oxidative phosphorylation in cancer cells, which might contribute to the observed anti-proliferation effects. Collectively, these results suggested that 54, 55, and 64 could be promising compounds for the development of potent PDK1 inhibitors.