113337-86-3Relevant academic research and scientific papers
An Efficient and Convenient Method for the Preparation of α-Methylenated Ketones from Silyl Enol Ethers
Hayashi, Masaji,Mukaiyama, Teruaki
, p. 1283 - 1286 (2007/10/02)
In the presence of a catalytic amount of stannous halide, silyl enol ethers react with bromomethyl methyl ether to give the corresponding α-bromoethyl ketones, which are smoothly converted to α-methylenated ketones on the successive addition of tertiary amine by one-pot procedure.This method is successfully applied to a synthesis of sarkomycin intermediate.
