1133388-13-2Relevant academic research and scientific papers
CHIRAL CONTROL
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Paragraph 00128, (2014/02/15)
The present invention relates to chirally controlled oligonucleotides, chirally controlled oligonucleotide compositions, and the method of making and using the same.
Stereocontrolled solid-phase synthesis of oligonucleoside H-phosphonates by an oxazaphospholidine approach
Iwamoto, Naoki,Oka, Natsuhisa,Sato, Terutoshi,Wada, Takeshi
supporting information; experimental part, p. 496 - 499 (2009/04/14)
(Chemical Equation Presented) Stereodefined oligonucleoside H-phosphonates were synthesized on a solid support using diastereopure nucleoside 3′-O-oxazaphospholidine monomers. Several stereodefined backbone-modified analogues were obtained with the oligonucleoside H-phosphonates as precursors (see scheme; BPRO = protected nucleobase, DMTr = 4,4′- dimethoxytrityl, Th = thymin-1-yl, TfO- = triflate).
