1133429-90-9Relevant academic research and scientific papers
Synthesis, β-adrenergic receptor binding and antihypertensive potential of vanillin-derived phenoxypropanolamines
Coumar, Mohane S.,Jindal, Dharam P.,Bruni, Giancarlo,Massarelli, Paola,Singh, Randhir,Sharma, Amit K.,Nandakumar,Bodhankar, Subhash L.
, p. 903 - 909 (2008/12/23)
Synthesis of vanillin-derived phenoxypropanolamines is carried out by condensing 4-hydroxy-3-methoxybenzaldehyde (vanillin) 1 with epichlorohydrin, followed by treatment with iso-propylamine or tert-butylamine to open the epoxy ring. Percentage inhibition of [3H]dihydroalprenolol binding to both β1- and β2-adrenergic receptors by the newly synthesized compounds is assessed in vitro using turkey erythrocyte membrane (β1) and lung homogenate of rats (β2). Formyl derivatives 8 and 9 showed maximum inhibitory effect in binding assay and are non-selective similar to propranolol. On the other-hand, aldoxime compounds 10 and 11 have preference for β1adrenergic receptors similar to atenolol. Also four of the compounds 8-11 are evaluated for their anti-hypertensive potential, in left renal artery ligation and fructose induced hypertension models. 4-(3-tert-Butylamino-2-hydroxy-propoxy)-3-methoxy- benzaldehyde oxime 11 shows antihypertensive effect better than propranolol.
