1133435-55-8

Basic information

• Product Name: 2-(2,4-dimethoxybenzyl)-4-oxo-1,2,3,4,4a,9b-hexahydrobenzo[4,5]thieno[3,2-c]pyridine-3-carboxylic acid methyl ester
• Synonyms: 2-(2,4-dimethoxybenzyl)-4-oxo-1,2,3,4,4a,9b-hexahydrobenzo[4,5]thieno[3,2-c]pyridine-3-carboxylic acid methyl ester
• CAS NO: 1133435-55-8
• Molecular Weight: 411.478
• Mol File: 1133435-55-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(2,4-dimethoxybenzyl)-4-oxo-1,2,3,4,4a,9b-hexahydrobenzo[4,5]thieno[3,2-c]pyridine-3-carboxylic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2,4-dimethoxybenzyl)-4-oxo-1,2,3,4,4a,9b-hexahydrobenzo[4,5]thieno[3,2-c]pyridine-3-carboxylic acid methyl ester(1133435-55-8)
• EPA Substance Registry System: 2-(2,4-dimethoxybenzyl)-4-oxo-1,2,3,4,4a,9b-hexahydrobenzo[4,5]thieno[3,2-c]pyridine-3-carboxylic acid methyl ester(1133435-55-8)

Safety Data

• Hazardous Substances Data: 1133435-55-8(Hazardous Substances Data)

Upstream product

• 1133435-54-7 3-{[(2,4-dimethoxybenzyl)ethoxycarbonylmethylamino]methyl}benzo[b]thiophene-2-carboxylic acid methyl ester 
• 3133-81-1 3-methylbenzo[b]thiophene-2-carboxylic acid methyl ester 

Relevant articles and documents

[(4-Hydroxyl-benzo[4,5]thieno[3,2-c]pyridine-3-carbonyl)-amino]-acetic acid derivatives; HIF prolyl 4-hydroxylase inhibitors as oral erythropoietin secretagogues

A new series of PHD (HIF prolyl 4-hydroxylase) inhibitors was designed based on the X-ray co-crystal structure of FG-2216. Using a lead generation process, a series of [(4-Hydroxyl-benzo[4,5]thieno[3,2-c]pyridine-3-carbonyl)- amino]-acetic acid derivatives was developed as potent PHD2 inhibitors. This class of compounds also showed the ability to stabilize HIF-α, to stimulate EPO secretion in in vitro studies, and to increase hematocrit, red blood cell count, and hemoglobin levels in an animal efficacy study.