1133438-87-5

Basic information

• Product Name: methyl 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-1,2,3-triazole-4-carboxylate
• Synonyms: methyl 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-1,2,3-triazole-4-carboxylate
• CAS NO: 1133438-87-5
• Molecular Weight: 382.633
• Mol File: 1133438-87-5.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: methyl 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-1,2,3-triazole-4-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-1,2,3-triazole-4-carboxylate(1133438-87-5)
• EPA Substance Registry System: methyl 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-1,2,3-triazole-4-carboxylate(1133438-87-5)

Safety Data

• Hazardous Substances Data: 1133438-87-5(Hazardous Substances Data)

Upstream product

• 7560-44-3 methyl 4-chlorocinnamate 
• 6921-40-0 1-azidonaphthalene 
• 873-73-4 4-n-chlorophenylacetylene 
• 1965-25-9 1-azido-2,4-dichlorobenzene 
• 79-22-1 methyl chloroformate 

Downstream Products

• 1133438-96-6 HS₅₇-7 

Relevant articles and documents

Lewis base catalyzed aerobic oxidative intermolecular azide-zwitterion cycloaddition

The discovery of a novel aerobic oxidative intermolecular azide-zwitterion reaction catalyzed by an organocatalyst is presented. It is demonstrated that the merger of the Lewis base 1,8-diazabicyclo[5.4.0]undec-7-ene and electrondeficient olefins generates reactive zwitterion intermediates, which readily participate in cycloaddition reactions with an array of azides, thus providing facile entry to fully or highly substituted 1,2,3-triazole frameworks. The reaction features an excellent substrate scope, and the products are obtained with high yields and excellent regioselectivities. It is demonstrated that some of these products can be transformed into pharmaceutically important agents. In addition to the experimental results, a detailed mechanistic survey is also provided, including MS studies rationalizing the origin of regioselective control.