1133862-72-2Relevant academic research and scientific papers
Cu/HP20-catalyzed solvent-free huisgen cycloaddition at ordinary temperatures
Kitamura, Yoshiaki,Taniguchi, Kazumi,Maegawa, Tomohiro,Monguchi, Yasunari,Kitade, Yukio,Sajiki, Hironao
, p. 233 - 243 (2014/01/17)
We have developed an environmentally friendly and highly efficient solvent-free Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) reaction using a polymer-supported copper catalyst (Cu/HP20). Substrates poorly soluble in common organic solvents are also
Water-soluble NHC-Cu catalysts: Applications in click chemistry, bioconjugation and mechanistic analysis
Daz Velzquez, Heriberto,Ruiz Garca, Yara,Vandichel, Matthias,Madder, Annemieke,Verpoort, Francis
supporting information, p. 9350 - 9356 (2014/12/11)
Copper(i)-catalyzed 1,3-dipolar cycloaddition of azides and terminal alkynes (CuAAC), better known as "click" reaction, has triggered the use of 1,2,3-triazoles in bioconjugation, drug discovery, materials science and combinatorial chemistry. Here we report a new series of water-soluble catalysts based on N-heterocyclic carbene (NHC)-Cu complexes which are additionally functionalized with a sulfonate group. The complexes show superior activity towards CuAAC reactions and display a high versatility, enabling the production of triazoles with different substitution patterns. Additionally, successful application of these complexes in bioconjugation using unprotected peptides acting as DNA binding domains was achieved for the first time. Mechanistic insight into the reaction mechanism is obtained by means of state-of-the-art first principles calculations.
Copper/HP20: Novel and polymer-supported copper catalyst for huisgen cycloaddition
Kitamura, Yoshiaki,Taniguchi, Kazumi,Maegawa, Tomohiro,Monguchi, Yasunari,Kitade, Yukio,Sajiki, Hironao
experimental part, p. 521 - 532 (2009/09/06)
A polymer-supported copper catalyst (Cu/HP20) is easily prepared in water and effectively catalyzed the Huisgen cycloaddition between azides and terminal alkynes.
