113397-69-6

Upstream product

• 711-41-1 2,3-dinitro-p-xylene 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 
• 1188-33-6 N,N-dimethylformamide diethyl diacetal 

Downstream Products

• 66-71-7 1,10-Phenanthroline 
• 484-11-7 2.9-dimethyl-1,10-phenanthroline 
• 773883-32-2 2,9-di(pyridin-2-yl)-1,10-phenanthroline 

Relevant academic research and scientific papers

Preparation of a New Friedl?nder Synthon, 2,3-Diaminobenzene-1,4-dicarbaldehyde, and Its Application towards Synthesis of 1,10-Phenanthrolines and Related Cyclophane

A new Friedl?nder synthon, 2,3-diaminobenzene-1,4-dicarbaldehyde, was prepared from p-xylene in 4 steps, of which the Friedl?nder reaction with acetaldehyde and acetone in a Schulenk bottle afforded 1,10-phenathroline and neocuprine in 44% and 82% yield, respectively. The scope of the Friedl?nder reactions of 2,3-diaminobenzene-1,4-dicarbaldehyde, including the synthesis of hexaazacyclic cyclophane with 1,10-phenanthroline and pyridine units, was described.

Expeditious Synthesis of Dihydrobenzo--, , and -dipyrroles

A simple, high-yield, two-step synthesis of the title compounds (1)-(3) is described, based on the catalytic reduction of the bis-enamines (4)-(6), in turn obtained by condensation of dimethylformamide diethyl acetal with the appropriate dinitro-xylene.