113420-85-2

Basic information

• Product Name: (1'S^*,5R^*)-3-(1'-phenyleth-1'-yl)-5-(hydroxymethyl)oxazolidin-2-one
• CAS NO: 113420-85-2
• Molecular Weight: 221.256
• Mol File: 113420-85-2.mol

Chemical Properties

• CAS DataBase Reference: (1'S^*,5R^*)-3-(1'-phenyleth-1'-yl)-5-(hydroxymethyl)oxazolidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (1'S^*,5R^*)-3-(1'-phenyleth-1'-yl)-5-(hydroxymethyl)oxazolidin-2-one(113420-85-2)
• EPA Substance Registry System: (1'S^*,5R^*)-3-(1'-phenyleth-1'-yl)-5-(hydroxymethyl)oxazolidin-2-one(113420-85-2)

Safety Data

• Hazardous Substances Data: 113420-85-2(Hazardous Substances Data)

Upstream product

• 113420-83-0 (1'S^*,5R^*)-3-(1'-phenyleth-1'yl)-5-(iodomethyl)oxazolidin-2-one 
• 113471-09-3 (S)-N-(1-phenyleth-1-yl)-N-(prop-2-en-1-yl)-N-(benzyloxycarbonyl)amine 
• 2627-86-3 (S)-1-phenyl-ethylamine 
• 113420-84-1 (1'S^*,5R^*)-3-(1'-phenyleth-1'-yl)-5-(acetoxymethyl)oxazolidin-2-one 
• 113420-76-1 (S)-N-(1-phenyleth-1-yl)-N-(prop-2-en-1-yl)amine hydrobromide 

Relevant articles and documents

AN EFFICIENT SYNTHESIS OF (R)-(+)- AND (S)-(-)-PROPRANOLOL FROM RESOLVED 5-IODOMETHYLOXAZOLIDIN-2-ONES

(1'S*,5S,R)-3-(1'-phenyleth-1'-yl)-5-iodomethyloxazolidin-2-ones, 4a,b, have been synthesized and easily resolved by silica gel chromatography.Each pure diastereomer has been then converted to (S)-(-)-propranolol 1a and (R)-(+)-propranolol 1b, respectively.An empirical correlation of configuration and 1H NMR chemical shift for alternate diastereomers has been devised and has proved to be applicable in assigning the configuration of 5-substituted 3-(1'-phenyleth-1'-yl)oxazolidin-2-ones.