113427-24-0 Usage
Clinical Use
Epoetin Alfa, recombinant Erythropoietin alfa, Epogen,Procrit, is a glycoprotein that stimulates red blood cellproduction. It is produced in the kidney, and it activates theproliferation and differentiation of specially committed erythroidprogenitors in the bone marrow.Epoetin is indicated to treat anemia of chronic renal failurepatients, anemia in zidovudine-treated HIV-infectedpatients, and in cancer patients taking chemotherapy. Theresults in these cases have been dramatic; most patients respondwith a clinically significant increase in hematocrit.
Veterinary Drugs and Treatments
EPO has been used to treat dogs and cats for anemia associated with
chronic renal
failure. Some clinicians state that because of the expense
and potential risks associated with its use, PCV’s should be in
the “teens” before considering beginning EPO therapy. Development
of antibodies to EPO has severely limited its clinical usefulness in
veterinary medicine for chronic use. EPO may be demonstrated in
the future to have significant benefits in reducing the number or
volume of transfusions, or as a neuroprotective agent.
Drug interactions
Potentially hazardous interactions with other drugs
Hyperkalaemia with ACE inhibitors and
angiotensin-II antagonists
Metabolism
The metabolic fate of both endogenous and recombinant
erythropoietin is poorly understood. Current evidence
from studies in animals suggests that hepatic metabolism
contributes only minimally to elimination of the intact
hormone, but desialylated epoetin (i.e. terminal sialic
acid groups removed) appears to undergo substantial
hepatic clearance via metabolic pathways and/or binding.
Desialylation and/or removal of the oligosaccharide side
chains of erythropoietin appear to occur principally in
the liver; bone marrow also may have a role in catabolism
of the hormone. Elimination of desialylated drug by the
kidneys, bone marrow, and spleen also may occur; results
of animal studies suggest that proximal renal tubular
secretion may be involved in renal elimination.
Check Digit Verification of cas no
The CAS Registry Mumber 113427-24-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,3,4,2 and 7 respectively; the second part has 2 digits, 2 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 113427-24:
(8*1)+(7*1)+(6*3)+(5*4)+(4*2)+(3*7)+(2*2)+(1*4)=90
90 % 10 = 0
So 113427-24-0 is a valid CAS Registry Number.
