113432-82-9

Basic information

• Product Name: 4-(2'-[methoxycarbonyl]phenyl)-4-oxobutanoic acid
• Synonyms: 4-(2'-[methoxycarbonyl]phenyl)-4-oxobutanoic acid
• CAS NO: 113432-82-9
• Molecular Weight: 236.224
• Mol File: 113432-82-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-(2'-[methoxycarbonyl]phenyl)-4-oxobutanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2'-[methoxycarbonyl]phenyl)-4-oxobutanoic acid(113432-82-9)
• EPA Substance Registry System: 4-(2'-[methoxycarbonyl]phenyl)-4-oxobutanoic acid(113432-82-9)

Safety Data

• Hazardous Substances Data: 113432-82-9(Hazardous Substances Data)

Upstream product

• 1094677-72-1 methyl 2-(4'-tert-butoxy-4'-oxobutanoyl)benzoate 
• 27415-09-4 4-(2'-carboxyphenyl)-4-oxobutanoic acid 
• 97204-49-4 4-[2-(Imidazole-1-carbonyl)-phenyl]-4-oxo-butyric acid 
• 97204-51-8 1-[2-(Imidazole-1-carbonyl)-phenyl]-4-imidazol-1-yl-butane-1,4-dione 

Downstream Products

• 1094677-99-2 6-N-t-butoxycarbonyl-2',3'-O-isopropylidene-5'-N-(N-[4''-(2'''-[methoxycarbonyl]phenyl)-4''-oxobutanoyl]sulfamoyl)aminodeoxyadenosine 
• 1094677-82-3 6-N-bis-t-butoxycarbonyl-2',3'-O-isopropylidene-5'-O-(N-[4''-(2'''-[methoxycarbonyl]-phenyl)-4''-oxobutanoyl]sulfamoyl)adenosine 

Relevant articles and documents

Mechanism-based inhibitors of MenE, an acyl-CoA synthetase involved in bacterial menaquinone biosynthesis

Menaquinone (vitamin K2) is an essential component of the electron transfer chain in many pathogens, including Mycobacterium tuberculosis and Staphylococcus aureus, and menaquinone biosynthesis is a potential target for antibiotic drug discovery. We report herein a series of mechanism-based inhibitors of MenE, an acyl-CoA synthetase that catalyzes adenylation and thioesterification of o-succinylbenzoic acid (OSB) during menaquinone biosynthesis. The most potent compound inhibits MenE with an IC50 value of 5.7 μM.