1134327-96-0

Basic information

• Product Name: IMidazo[1,2-a]pyridine-3-carbonitrile, 6-fluoro-
• Synonyms: IMidazo[1,2-a]pyridine-3-carbonitrile, 6-fluoro-
• CAS NO: 1134327-96-0
• Molecular Formula: C₈H₄FN₃
• Molecular Weight: 161.1358632
• Mol File: 1134327-96-0.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• Density: 1.34±0.1 g/cm3(Predicted)
• PKA: 1.07±0.50(Predicted)
• CAS DataBase Reference: IMidazo[1,2-a]pyridine-3-carbonitrile, 6-fluoro-(CAS DataBase Reference)
• NIST Chemistry Reference: IMidazo[1,2-a]pyridine-3-carbonitrile, 6-fluoro-(1134327-96-0)
• EPA Substance Registry System: IMidazo[1,2-a]pyridine-3-carbonitrile, 6-fluoro-(1134327-96-0)

Safety Data

• Hazardous Substances Data: 1134327-96-0(Hazardous Substances Data)

Usage

General Description

Imidazo[1,2-a]pyridine-3-carbonitrile, 6-fluoro- is a chemical compound with the molecular formula C9H4FN3. It is a derivative of imidazopyridine, which is a heterocyclic compound containing both imidazole and pyridine rings. The presence of a fluoro group at the sixth position of the pyridine ring makes this compound a fluorinated derivative. Imidazo[1,2-a]pyridine-3-carbonitrile, 6-fluoro- has potential applications in medicinal chemistry and drug development due to its unique structure and potential biological activities. Imidazo[1,2-a]pyridine-3-carbonitrile, 6-fluoro- may have relevance in the development of novel pharmaceuticals targeting specific biological pathways or protein interactions. Further research and studies are necessary to explore the full potential and applications of this chemical.

Upstream product

• 60838-50-8 3-methoxy-2-propenenitrile 
• 21717-96-4 2-amino-5-fluoropyridine 
• 106-96-7 propargyl bromide 
• 69194-03-2 3-methoxy-2-propenenitrile 

Downstream Products

• 1220039-94-0 6-fluoroimidazo[1,2-a]pyridine-3-carboximidamide 
• 1313279-95-6 (R)-benzyl 4-(6-(1-(tert-butoxycarbonyl)piperidin-3-ylamino)-2-(6-fluoroimidazo[1,2-a]pyridin-3-yl)pyrimidin-4-yl)piperazine-1-carboxylate 
• 1352623-96-1 (S)-2-(6-fluoroimidazo[1,2-a]pyridin-3-yl)-5-nitro-N-(1-phenylethyl)pyrimidin-4-amine 

Relevant articles and documents

Identification of 2-Imidazopyridine and 2-Aminopyridone Purinones as Potent Pan-Janus Kinase (JAK) Inhibitors for the Inhaled Treatment of Respiratory Diseases

Janus kinases (JAKs) have a key role in regulating the expression and function of relevant inflammatory cytokines involved in asthma and chronic obstructive pulmonary disease. Herein are described the design, synthesis, and pharmacological evaluation of a series of novel purinone JAK inhibitors with profiles suitable for inhaled administration. Replacement of the imidazopyridine hinge binding motif present in the initial compounds of this series with a pyridone ring resulted in the mitigation of cell cytotoxicity. Further systematic structure-activity relationship (SAR) efforts driven by structural biology studies led to the discovery of pyridone 34, a potent pan-JAK inhibitor with good selectivity, long lung retention time, low oral bioavailability, and proven efficacy in the lipopolysaccharide-induced rat model of airway inflammation by the inhaled route.

IMIDAZOLOPYRIMIDIN-2-YL DERIVATIVES AS JAK INHIBITORS

New imidazopyridmin-2-yl derivatives are disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use as inhibitors of Janus Kinases (JAK) for the treatment of myeloproliferative disorders, leukemia, lymphoid malignancies and solid tumors; bone marrow and organ transplant rejection; immune-mediated diseases and inflammatory diseases.

HETEROARYL IMIDAZOLONE DERIVATIVES AS JAK INHIBITORS

New heteroaryl imidazolone derivatives having the chemical structure of formula (I) disclosed; as well as process for their preparation, pharmaceutical compositions comprising them and their use in therapy as inhibitors of Janus Kinases (JAK).