113447-03-3Relevant academic research and scientific papers
FUSED HETEROCYCLIC COMPOUNDS USEFUL AS INHIBITORS OF HISTONE DEACETYLASE
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Page/Page column 172-175, (2008/06/13)
Disclosed are compounds of formula (I) that inhibit histone deacetylase (HDAC) enzymatic activity, pharmaceutical compositions comprising such compounds, as well as methods to treat conditions, particularly proliferative conditions, mediated at least in part by HDAC, wherein A, W, W1, W2, Ar2, and G are described herein.
Indole derivatives
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, (2008/06/13)
New indole derivatives of the general formula I STR1 in which Ind is a 3-indolyl radical which can be substituted by a hydroxymethyl, methylenedioxy, S-alkyl, SO-alkyl, SO2 -alkyl, CN or COW group and/or can be substituted once or twice by alkyl, O-alkyl, OH, F, Cl or Br, W is H, OH, O-alkyl, NH2, NH-alkyl or N(alkyl)2, A is --(CH2)n --, --CH2 --S--CH2 CH2 --, --CH2 --SO--CH2 CH2 -- or --CH2 --SO2 --CH2 CH2 --, is --(CH2)m --, --CH=CH--, --CHOH--, --CO--, S, SO, SO2 or O, n is 2, 3, 4 or 5 and m is 1, 2 or 3, in which the alkyl groups each have 1-4 C atoms, and their salts, have effects on the central nervous system.
Synthesis of the 1,2,3,4-Tetrahydrobenzofuropyridine Ring System
Jaen, Juan C.,Wise, Lawrence D.
, p. 1317 - 1319 (2007/10/02)
As part of an on-going research project, we required an efficient method for the preparation of compounds containing the 1,2,3,4-tetrahydrobenzofuropyridine ring nucleus.The parent compound 1 has not been described in the literature, and there is o
