1134559-06-0

Upstream product

• 1001057-04-0 2-bromo-5-nitrobenzylamine 
• 24424-99-5 di-tert-butyl dicarbonate 
• 3959-05-5 2-bromobenzylamine 
• 34158-72-0 2-bromobenzaldehyde oxime 

Downstream Products

• 1134559-49-1 (5-amino-2-bromobenzyl)carbamic acid t-butyl ester 
• 1541897-97-5 7-nitro-3-phenylisoquinoline 
• 1422040-86-5 C₄₂H₄₅N₅O₄ 
• 1422041-09-5 C₁₆H₁₉N₃ 
• 1422041-02-8 C₂₄H₂₃N₃O₄ 
• 1422041-01-7 C₂₃H₂₁N₃O₄ 

Relevant academic research and scientific papers

Palladium-Catalyzed α-Arylation of Silylenol Ethers in the Synthesis of Isoquinolines and Phenanthridines

A diverse array of isoquinolines and phenanthridines have been accessed by developing a two-step, one-pot method constituting regioselective palladium-catalyzed Kuwajima-Urabe α-arylation of silylenol ethers and acid-mediated deprotection, annulation, and aromatization. Structural diversity in the silylenol ethers leads to three different classes of isoquinolines and phenanthridines from which related natural products can be derived. The synthetic utility of this method by the quick assembly of the natural product trispheridine is also demonstrated.

2,3-DIHYDRO-IMINOISOINDOLE DERIVATIVES

A compound represented by the following general formula (1), or a salt thereof has serine protease inhibiting activity, and particularly excellent inhibiting activity against clotting factor VIIa. This compound or a salt thereof is useful as therapeutic and/or prophylactic agents for diseases associated with thrombus formation. [wherein R1 represents hydrogen, R2 represents optionally substituted phenyl, etc., R3 represents optionally substituted C6-10 aryl, etc.]