1134563-99-7Relevant academic research and scientific papers
Base-mediated cascade rearrangements of aryl-substituted diallyl ethers
Reid, Jolene P.,McAdam, Catherine A.,Johnston, Adam J. S.,Grayson, Matthew N.,Goodman, Jonathan M.,Cook, Matthew J.
, p. 1472 - 1498 (2015/02/19)
Two base-mediated cascade rearrangement reactions of diallyl ethers were developed leading to selective [2,3]-Wittig-oxy-Cope and isomerization-Claisen rearrangements. Both diaryl and arylsilyl-substituted 1,3-substituted propenyl substrates were examined, and each exhibits unique reactivity and different reaction pathways. Detailed mechanistic and computational analysis was conducted, which demonstrated that the role of the base and solvent was key to the reactivity and selectivity observed. Crossover experiments also suggest that these reactions proceed with a certain degree of dissociation, and the mechanistic pathway is highly complex with multiple competing routes.
Copper-catalyzed oxaziridine-mediated oxidation of C-H bonds
Motiwala, Hashim F.,Guelgeze, Belgin,Aube, Jeffrey
experimental part, p. 7005 - 7022 (2012/10/08)
The highly regio- and chemoselective oxidation of activated C-H bonds has been observed via copper-catalyzed reactions of oxaziridines. The oxidation proceeded with a variety of substrates, primarily comprising allylic and benzylic examples, as well as one example of an otherwise unactivated tertiary C-H bond. The mechanism of the reaction is proposed to involve single-electron transfer to the oxaziridines to generate a copper-bound radical anion, followed by hydrogen atom abstraction and collapse to products, with regeneration of the catalyst by a final single-electron transfer event. The involvement of allylic radical intermediates was supported by a radical-trapping experiment with TEMPO.
Studies on the amino-heck reactions of unsaturated ketones o-phosphinyloximes for the preparation of substituted pyridines
Zhu, Jia-Liang,Su, Yi-Lin,Chan, Yu-Hui,Chen, I-Chia,Liao, Chuan-Chen
scheme or table, p. 369 - 387 (2009/06/08)
The amino-Heck cyclization process has been applied into a range of γ,δ-unsaturated ketone O-diethylphosphinyloximes 1 and δ,ε-unsaturated ketone O-diethylphosphinyloximes 7. Under the specific catalytic conditions developed by us, these substrates were found to preferentially undergo the 6-endo cyclization to give the formation of 2-substituted pyridines 3 and substituted methylpyridines 8, respectively, in moderate to good yields. Besides, several interesting aspects on the effects of phosphinyl groups, solvents, bases and molecular sieves on the regioselectivity of the cyclization of 1 have also been realized.
