113457-05-9 Usage
Uses
Used in Oncology:
Ledoxantrone is used as an antineoplastic agent for the treatment of various types of cancer. It is particularly effective against solid tumors due to its ability to inhibit DNA synthesis and topoisomerase II activity, leading to the prevention of cancer cell proliferation and induction of apoptosis.
Used in Drug Development:
Ledoxantrone Trihydrochloride has superseded Sedoxantrone Trihydrochloride in drug development, indicating its potential as a more effective and safer alternative for cancer treatment. Its unique mechanism of action and improved pharmacological properties make it a promising candidate for further research and development in oncology.
Check Digit Verification of cas no
The CAS Registry Mumber 113457-05-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,3,4,5 and 7 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 113457-05:
(8*1)+(7*1)+(6*3)+(5*4)+(4*5)+(3*7)+(2*0)+(1*5)=99
99 % 10 = 9
So 113457-05-9 is a valid CAS Registry Number.
InChI:InChI=1/C21H27N5OS.3ClH/c1-3-25(4-2)11-12-26-17-8-7-16(23-10-9-22)21-19(17)20(24-26)15-6-5-14(27)13-18(15)28-21;;;/h5-8,13,23,27H,3-4,9-12,22H2,1-2H3;3*1H
113457-05-9Relevant academic research and scientific papers
Processes for the preparation of benzo(chalcogeno)(4,3,2-cd)indazoles and intermediates thereof
-
, (2008/06/13)
Improved processes for producing substituted benzo(chalcogeno)[4,3,2-cd] indazoles. The processes produce compounds in higher yields and of greater purity by using a novel sequence of acylation chemistry and easily removed protecting groups. The compounds produced have antibacterial, antifungal, antileukemic, and antitumor activity.
Benzothiopyranoindazoles, a new class of chromophore modified anthracenedione anticancer agents. Synthesis and activity against murine leukemias
Hollis Showalter,Angelo,Berman,Kanter,Ortwine,Ross-Kesten,Sercel,Turner,Werbel,Worth,Elslager,Leopold,Shillis
, p. 1527 - 1539 (2007/10/02)
The synthesis of the benzothiopyranoindazoles (3), a new class of chromophore modified anthracenediones related to mitoxantrone (1), is described. In this structural class the quinone moiety, which is believed to be responsible for the cardiotoxicity of t
