1134633-75-2Relevant academic research and scientific papers
Synthesis and characterization of some novel quinolinothiazines of biological interest
Kalluraya, Balakrishna,Nayak, Janardhana,Adhikari, Adithya,Sujith,Shetty, N. Sucheta,Winter, Manuela
experimental part, p. 1870 - 1883 (2009/08/07)
A series of 3-aryl-4H-5-(61/81-substituted-31-formyl-21-quinolinyl) thia-1,2,4-triazoles were prepared by the reaction of 2-chloro-3-formyl-6/8- substituted quinoline with 3-substituted 4H-5-mercapto-1,2,4-triazole. These thia-triazoles 5 on reaction with substituted acetophenone gave a novel series of 2-substituted-s-triazolo[5,1-b]-6/8-substituted quinolino-9-arylacetyl[1,3] thiazines 8 rather than the expected 1-aryl-3-[21-(5-substituted-4H-1,2,4- triazole-5-thia)-61/81-substituted quinoline-31-yl]-2-propen-1-ones 7. The new compounds were screened for their antibacterial activity against Gram-positive and Gram-negative bacteria and antifungal activity against Candida albicans. Most of the tested compounds showed significant antibacterial activity much higher than that of the standard drug Nitrofurazone. The structures of the new compounds were established based on analytical and spectral data. In a typical example, the structure of thiazine 8e was further confirmed by single crystal x-ray data. Copyright Taylor & Francis Group, LLC.
