1134639-23-8 Usage
Chemical Properties
Yellow Solid
Uses
Protected Curcumin (C838500). A natural phenolic compound. Potent anti-tumor agent having anti-inflammatory and anti-oxidant properties. Induces apoptosis in cancer cells and inhibits phorbol ester-induced protein kinase C (PKC) activity. Reported to inhibit production of inflammatory cytokines by peripheral blood monocytes and alveolar macrophages. Potent inhibitor of EGFR tyrosine kinase and IκB kinase. Inhibits inducible nitric oxide synthase (iNOS), cycloxygenase and lipoxygenase. Easily penetrates into the cytoplasm of cells, accumulating in membranous structures such as plasma membrane, endoplasmic reticulum and nuclear envelope.
Check Digit Verification of cas no
The CAS Registry Mumber 1134639-23-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,3,4,6,3 and 9 respectively; the second part has 2 digits, 2 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 1134639-23:
(9*1)+(8*1)+(7*3)+(6*4)+(5*6)+(4*3)+(3*9)+(2*2)+(1*3)=138
138 % 10 = 8
So 1134639-23-8 is a valid CAS Registry Number.
1134639-23-8Relevant articles and documents
Influence of side-chain changes on histone deacetylase inhibitory and cytotoxicity activities of curcuminoid derivatives
Kumboonma, Pakit,Phaosiri, Chanokbhorn,Saenglee, Somprasong,Samankul, Arunta,Senawong, Gulsiri,Senawong, Thanaset,Somsakeesit, La-or,Yenjai, Chavi
supporting information, (2020/04/10)
Using curcuminoids as lead compounds, fifty-nine curcuminoid derivatives with different side chains at the phenolic moiety were synthesized. All compounds were investigated for their histone deacetylase (HDAC) inhibitory activities. The potent pan-HDAC in
