1134647-21-4

Basic information

• Product Name: 4-methylumbelliferyl 3,6-di-O-acetyl-2,4-dideoxy-2-trifluoroacetamido-4-fluoro-β-D-glucopyranoside
• CAS NO: 1134647-21-4
• Molecular Weight: 519.404
• Mol File: 1134647-21-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-methylumbelliferyl 3,6-di-O-acetyl-2,4-dideoxy-2-trifluoroacetamido-4-fluoro-β-D-glucopyranoside(CAS DataBase Reference)
• NIST Chemistry Reference: 4-methylumbelliferyl 3,6-di-O-acetyl-2,4-dideoxy-2-trifluoroacetamido-4-fluoro-β-D-glucopyranoside(1134647-21-4)
• EPA Substance Registry System: 4-methylumbelliferyl 3,6-di-O-acetyl-2,4-dideoxy-2-trifluoroacetamido-4-fluoro-β-D-glucopyranoside(1134647-21-4)

Safety Data

• Hazardous Substances Data: 1134647-21-4(Hazardous Substances Data)

Upstream product

• 67909-31-3 4-methyl-7-(trimethylsilyloxy)-2H-1-benzopyran-2-one 
• 1134647-20-3 3,6-di-O-acetyl-2,4-dideoxy-2-trifluoroacetamido-4-fluoro-α-D-glucopyranosyl fluoride 

Relevant articles and documents

A short synthesis of 4-deoxy-4-fluoroglucosaminides: Methylumbelliferyl N-acetyl-4-deoxy-4-fluoro-β-D-glucosaminide

A convenient method of synthesis of 1,6-anhydro-4-deoxy-2-O-tosyl-4-fluoro- β-D-glucopyranose by fusion of 1,6;3,4-dianhydro-2-O-tosyl-β-D- galactopyranose with 2,4,6-trimethylpyridinium fluoride was found. By a successive action of ammonia, methyl trifluoroacetate, and acetic anhydride, the resulting compound was transformed into 1,6-anhydro-3-O-acetyl-2,4-dideoxy-2- trifluoroacetamido-4-fluoro-β-D-glucopyranose, which was converted into 3,6-di-O-acetyl-2,4-dideoxy-2-trifluoroacetamido-4-fluoro-αD- glucopyranosyl fluoride by the reaction with HF/Py. The resulting fluoride was further used as a glycosyl donor in the synthesis of methylumbelliferyl N-acetyl-4-deoxy-4-fluoro-β-D-glucosaminide.