1134782-21-0

Basic information

• Product Name: (3α,5α,17β)-17-(p-toluene)androstane-3,17-diol
• Synonyms: (3α,5α,17β)-17-(p-toluene)androstane-3,17-diol
• CAS NO: 1134782-21-0
• Molecular Weight: 382.587
• Mol File: 1134782-21-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (3α,5α,17β)-17-(p-toluene)androstane-3,17-diol(CAS DataBase Reference)
• NIST Chemistry Reference: (3α,5α,17β)-17-(p-toluene)androstane-3,17-diol(1134782-21-0)
• EPA Substance Registry System: (3α,5α,17β)-17-(p-toluene)androstane-3,17-diol(1134782-21-0)

Safety Data

• Hazardous Substances Data: 1134782-21-0(Hazardous Substances Data)

Upstream product

• 106-38-7 para-bromotoluene 
• 53-41-8 cis-androsterone 

Downstream Products

• 1134782-22-1 (3α,5α)-17-(p-toluene)androst-16-en-3-ol 

Relevant articles and documents

Synthesis of fluorinated analogues of the neurosteroid GABAA receptor antagonist, 17-PA

The steroid 17-PA is a GABAA receptor antagonist which is finding use as a tool in evaluating agonistic/antagonistic activity at GABAA receptors. Compounds with improved efficacy over 17-PA would be are advantageous for such studies. Accordingly a series of novel analogues of the neurosteroid 17-PA have been prepared and a convenient two-step route is presented which is amenable to the synthesis of analogues with electron-donating para-aromatic substituents including fluorine. However, for the meta-fluoro analogue then the original four-step route to 17-PA remains more efficient overall. The paper describes these syntheses and discusses the electronic factors which influence this synthetic chemistry.