1135-40-6

Basic information

• Product Name: N-Cyclohexyl-3-aminopropanesulfonic acid
• Synonyms: CAPS 3-(Cyclohexylamino)-1-propanesulfonic acid;CAPS, Molecular Biology Grade 3-(Cyclohexylamino)-1-propanesulfonic acid, Molecular Biology Grade;CAPS, ULTROL Grade;3-cyclohexylaminopropane-1-sulphonic acid;CAPS, 99% (3-CYCLOHEXYLAMINO-1-PROPANE-S ULFONIC ACID);CHOLESTERYL PALMITATE 98+%;3-(CYCLOHEXYLAMINO)-PROPANE SULFONIC ACID (CAPS);CAPS, MOLECULAR BIOLOGY GRADE
• CAS NO: 1135-40-6
• Molecular Formula: C₉H₁₉NO₃S
• Molecular Weight: 221.32
• EINECS: 214-492-1
• Product Categories: Pharmaceutical Intermediates;buffer
• Mol File: 1135-40-6.mol
• Article Data: 4

Chemical Properties

• Melting Point: >300 °C(lit.)
• Flash Point: >110℃
• Appearance: White/Powder/Solid
• Density: 1.1809 (rough estimate)
• Vapor Pressure: 0Pa at 25℃
• Refractive Index: 1.5250 (estimate)
• Storage Temp.: Store at RT.
• Solubility: H2O: 0.5 M at 20 °C, clear
• PKA: 10.4(at 25℃)
• Water Solubility: 9 g/100 mL (20 ºC)
• Stability: Stable. Incompatible with strong oxidizing agents.
• Merck: 14,1767
• BRN: 2835588
• CAS DataBase Reference: N-Cyclohexyl-3-aminopropanesulfonic acid(CAS DataBase Reference)
• NIST Chemistry Reference: N-Cyclohexyl-3-aminopropanesulfonic acid(1135-40-6)
• EPA Substance Registry System: N-Cyclohexyl-3-aminopropanesulfonic acid(1135-40-6)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/38-36/37/38-22-20/21/22-40/22
• Safety Statements: 26-36/37/39-37/39-24/25-22-23-36
• WGK Germany: 3
• RTECS: TZ6395000
• F: 34
• TSCA: Yes
• Hazardous Substances Data: 1135-40-6(Hazardous Substances Data)

Usage

Chemical Properties

White/clear crystalline powder

Uses

Different sources of media describe the Uses of 1135-40-6 differently. You can refer to the following data:
1. Biological buffer.
2. CAPS (N-cyclohexyl-3-aminopropanesulfonic acid) buffer salt is used to formulate CAPS buffer, a zwitterionic buffer that is useful in the range of pH 7.9-11.1. CAPS buffer is widely used in Western and immunoblotting experiments as well as protein sequencing and identification. Used in the electrotransfer of proteins to PVDF (sc-3723) or nitrocellulose membranes (sc-3718,?sc-3724). The high pH of this buffer makes it useful for the transfer of proteins with a pI > 8.5. CAPS is not one of the original Good?s buffers, although it has a similar structure to the other propanesulfonic acids and was selected as a highly water soluble buffering reagent with an optimum buffering pH of 10.4 and minimal reactivity with enzymes or proteins, minimal salt effects.

Flammability and Explosibility

Notclassified

InChI:InChI=1/C9H19NO3S/c11-14(12,13)8-4-7-10-9-5-2-1-3-6-9/h9-10H,1-8H2,(H,11,12,13)

Synthetic route

3-(cyclohexylamino)propanesulfonic acid (1135-40-6) + 2-(4-chlorophenyl)-3-methyl-(2SR)-butanoyl chloride (51631-50-6) + 3-Phenoxybenzaldehyde (39515-51-0) → FENVALERATE (51630-58-1)

Conditions	Yield
In n-heptane; water
In n-heptane; water

permethric acid chloride (52314-67-7) + 3-(cyclohexylamino)propanesulfonic acid (1135-40-6) + 3-Phenoxybenzaldehyde (39515-51-0) → cypermethrine (52315-07-8)

Conditions	Yield
With sodium carbonate In n-heptane; water

3-(cyclohexylamino)propanesulfonic acid (1135-40-6) + tetra-n-butylphosphonium hydroxide (14518-69-5) → [TBP][CAPS]

Conditions	Yield
In water at 20℃;

3-(cyclohexylamino)propanesulfonic acid (1135-40-6) + tetramethyl ammoniumhydroxide (75-59-2) → C9H18NO3S(1-)*C4H12N(1+)

Conditions	Yield
In water at 20℃; for 12h;

3-(cyclohexylamino)propanesulfonic acid (1135-40-6) + tetraethylammonium hydroxide (77-98-5) → C9H18NO3S(1-)*C8H20N(1+)

Conditions	Yield
In water at 20℃; for 12h;

3-(cyclohexylamino)propanesulfonic acid (1135-40-6) + tetra(n-butyl)ammonium hydroxide (2052-49-5) → 3-Cyclohexylamino-propane-1-sulfonatetetrabutyl-ammonium; (113599-05-6)

Conditions	Yield
In water at 20℃; for 12h;

N,N-dimethyl-cyclohexanamine (98-94-2) + 3-(cyclohexylamino)propanesulfonic acid (1135-40-6) + Hexamethylene diisocyanate (822-06-0) → C17H31N3O5S*C8H17N

Conditions	Yield
at 80℃; for 3h;

hexamethylenediisocyanate uretdione (23501-81-7) + N,N-dimethyl-cyclohexanamine (98-94-2) + 3-(cyclohexylamino)propanesulfonic acid (1135-40-6) → C25H43N5O7S*C8H17N

Conditions	Yield
Heating;

3-(cyclohexylamino)propanesulfonic acid (1135-40-6) + TPO chloride → C32H39NO5PS(1-)*K(1+)

Conditions	Yield
With potassium carbonate In acetonitrile Reflux;

3-(cyclohexylamino)propanesulfonic acid (1135-40-6) + (3,5-bis(chloromethyl)-2,4,6-trimethylphenyl)(diphenylphosphoryl)methanone → C42H57N2O8PS2(2-)*2K(1+)

Conditions	Yield
With potassium carbonate In acetonitrile Reflux;

Downstream Products

• 113599-05-6 3-Cyclohexylamino-propane-1-sulfonatetetrabutyl-ammonium; 
• 52315-07-8 cypermethrine 
• 51630-58-1 FENVALERATE 

Relevant articles and documents

Isolation of nucleic acids

A method for extracting nucleic acids from a biological material such as blood comprises contacting the mixture with a material at a pH such that the material is positively charged and will bind negatively charged nucleic acids and then eluting the nucleic acids at a pH when the said materials possess a neutral or negative charge to release the nucleic acids. The nucleic acids can be removed under mildly alkaline conditions to the maintain integrity of the nucleic acids and to allow retrieval of the nucleic acids in reagents that are immediately compatible with either storage or analytical testing.

Use of zwitterionic compounds and their N-halo derivatives

Zwitterionic compounds selected from:, taurine (2-aminoethanesulphonic acid), 2(N-morpholino)ethanesulphonic acid (MES), N-(2-acetamido) iminodiacetic acid (ADA), piperazine-N,N?bis(2-ethanesulphonic acid (PIPES), N-(2-acetamido)-2-aminoethanesulphonic acid (ACES), N,N-bis(2-hydroxyethyl)-2-aminoethanesulphonic acid (BES), 3-(N-morpholino)propanesulphonic (MOPS), N-N[tris(hydroxymethyl)-methyl]-2-aminoethanesulphonic acid (TES), N-2-hydroxyethylpiperazine-N?-2-ethanesulphonic acid (HEPES), N-2-hydroxyethylpiperazine-N?3-propanesulphonic acid ((H)EPPS), 2-(cyclohexylamino) ethanesulphonic acid (CHES) or 3-(cyclohexylamino) propanesulphonic acid (CAPS), and their N-halo derivatives can be used separately or in combination in the treatment of related clinical conditions by stimulating myeloperoxidase activity, which in turn stimulates hypochlorous acid production in vivo, which leads inter aliato enhanced leukotriene inactivation.