1135120-27-2Relevant academic research and scientific papers
Discovery of thiophene inhibitors of polo-like kinase
Emmitte, Kyle A.,Andrews, C. Webb,Badiang, Jennifer G.,Davis-Ward, Ronda G.,Dickson, Hamilton D.,Drewry, David H.,Emerson, Holly K.,Epperly, Andrea H.,Hassler, Daniel F.,Knick, Victoria B.,Kuntz, Kevin W.,Lansing, Timothy J.,Linn, James A.,Mook Jr., Robert A.,Nailor, Kristen E.,Salovich, James M.,Spehar, Glenn M.,Cheung, Mui
scheme or table, p. 1018 - 1021 (2009/09/06)
The discovery and development of a series of thiophenes as potent and selective inhibitors of PLK is described. Identification and characterization of 2, a useful in vitro PLK inhibitor tool compound, is also presented.
