113520-22-2Relevant academic research and scientific papers
REACTION OF 3H-OXAZOLOPYRIDINE-2-THIONE WITH AMINES
Davidkov, K.,Simov, D.,Kalcheva, V.
, p. 905 - 906 (1987)
Primary amines and diethylamine react with oxazolopyridine thione to form N-(3-hydroxy-2-pyridyl)thioureas whereas cyclic secondary amines and aniline form 2-aminooxazolopyridines.Exchange of the benzene ring in benzoxazolinethione for pyrid
Synthesis and characterization of oxazolopyridine and benzoxazole derivatives
Venkatachalam,Pierens,Reutens
, p. 519 - 527 (2015/03/03)
Synthesis of piperazinyl-substituted oxazolopyridine and benzoxazole was achieved in three steps starting from aminophenol and carbon disulfide. Condensation of aminophenols with carbon disulfide in ethanol using potassium hydroxide as catalyst gave the required benzoxazole thiol in one step. Treatment of the thiol with piperazine and substituted piperazine derivatives in toluene furnished the titled compounds in good yield. We introduced halogen substitution in the pendant arm of the piperazine derivatives for versatile functionalization. We report the synthesis and characterization of these compounds using high resolution NMR techniques.
