1135242-13-5

Basic information

• Product Name: VU 0357017 hydrochloride
• Synonyms: VU 0357017 hydrochloride;4-[[2-[(2-Methylbenzoyl)aMino]ethyl]aMino]-1-piperidinecarboxylic Acid Ethyl Ester Hydrochloride;4-[[2-[(2-Methylbenzoyl)amino]ethyl]amino]-1-piperidinecarboxylic acid ethyl ester monohydrochloride;CID 25010775;ML071 hydrochloride;SID 56353039;VU0357017 monohydrochloride;VU0357017
• CAS NO: 1135242-13-5
• Molecular Formula: C18H28ClN3O3
• Molecular Weight: 369.9
• Product Categories: Amines;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Positive allosteric modulator of muscarinic M1 receptors.
• Mol File: 1135242-13-5.mol
• Article Data: 0

Chemical Properties

• Appearance: white to off-white/
• Storage Temp.: 2-8°C
• Solubility: DMSO: ≥10mg/mL
• CAS DataBase Reference: VU 0357017 hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: VU 0357017 hydrochloride(1135242-13-5)
• EPA Substance Registry System: VU 0357017 hydrochloride(1135242-13-5)

Safety Data

• Hazard Codes: N
• Statements: 52/53
• Safety Statements: 61
• WGK Germany: 2
• Hazardous Substances Data: 1135242-13-5(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 1135242-13-5 differently. You can refer to the following data:
1. VU0357017 is a subtype-selective M1 muscarinic acetylcholine allosteric agonist. VU0357017 has a potency of 200 nM and Achmax of 81% and had no activity at M2-M5 up to the highest concentrations tested and also had little or no detectable antagonist activity at any other mAChR subtype at concentrations over 2 orders of magnitude higher than those required to activate M1 or activity at a large panel of GPCRs, ion channels, and transporters. In contrast, TBPB inhibited responses to ACh at each of the other mAChR subtypes. VU0357017 was active in reversing cognitive deficits induced by Scopolamine (S200000) in a preclinical rodent model.
2. VU 0357017 Hydrochloride is a cholinergic M1 receptor antagonist and a cholinomimetic agent used for the treatment of behavioral and/or mental disorders.